Brush copolymers
View Patent ↗Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed.
1. A brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated boronic acid-containing monomer and (b) a macromonomer having hydrophilic units and boronic acid units, wherein the ethylenically unsaturated boronic acid-containing monomer is an ethylenically unsaturated aryl boronic acid.
2. The brush copolymer of claim 1 , wherein the ethylenically unsaturated boronic acid-containing monomer is selected from the group consisting of 4-vinylphenylboronic acid, 3-methacrylamidophenylboronic acid, 3-acrylamidophenylboronic acid and mixtures thereof.
3. The brush copolymer of claim 1 , wherein the brush copolymer further comprises monomeric units containing a tertiary-amine moiety.
4. The brush copolymer of claim 1 , wherein the brush copolymer further comprises monomeric units containing a hydrophilic moiety capable of rendering the brush copolymer water-soluble.
5. The brush copolymer of claim 4 , wherein the monomeric unit containing a hydrophilic moiety capable of rendering the brush copolymer water-soluble is selected from the group consisting of N-vinyl pyrrolidone, N-vinyl-N-methyl acetamide, N,N-dimethyl methacrylamide, N,N-dimethylacrylamide, and mixtures thereof.
6. The brush copolymer of claim 3 , comprising
about 1 to about 20 mole percent of the ethylenically unsaturated boronic acid-containing monomeric units,
about 1 to about 20 mole percent of the macromonomer having hydrophilic units and boronic acid units,
about 1 to about 20 mole percent of monomeric units derived from an ethylenically unsaturated monomer containing a tertiary-amine moiety, and
about 40 to about 90 mole percent of monomeric units derived from an ethylenically unsaturated monomer containing a hydrophilic moiety capable of rendering the brush copolymer water-soluble.
7. A biomedical device having a coating on a surface thereof, the coating comprising the brush copolymer of claim 1 , wherein the ethylenically unsaturated boronic acid-containing monomer is an ethylenically unsaturated aryl boronic acid.
8. A biomedical device having a coating on a surface thereof, the coating comprising the brush copolymer of claim 1 , wherein the ethylenically unsaturated boronic acid-containing monomer is selected from the group consisting of 4-vinylphenylboronic acid, 3-methacrylamidophenylboronic acid, 3-acrylamidophenylboronic acid and mixtures thereof.
9. A biomedical device having a coating on a surface thereof, the coating comprising the brush copolymer of claim 1 , wherein the brush copolymer further comprises monomeric units containing a hydrophilic moiety capable of rendering the brush copolymer water-soluble, and further wherein the hydrophilic moiety capable of rendering the brush copolymer water-soluble is selected from the group consisting of N-vinyl pyrrolidone, N-vinyl-N-methyl acetamide, N,N-dimethyl methacrylamide, N,N-dimethylacrylamide, and mixtures thereof.