Drug-eluting rotational spun coatings and methods of use
View Patent ↗Drug-eluting rotational spun coatings that include one or more therapeutic agents may be used to coat a medical device. The medical devices include, for example, balloon catheters, vascular grafts and stents, which are coated with drug-eluting rotational spun materials that may be used to deliver a therapeutic agent to a target tissue or body lumen.
1. A medical device comprising a drug-eluting rotational spun coating, wherein the drug-eluting rotational spun coating comprises a therapeutic agent in an amount configured to deliver a pharmaceutically effective dose to a target tissue, wherein the drug-eluting rotational spun coating is configured to provide a controlled release of the therapeutic agent to the target issue in approximately 5 minutes or less, wherein the drug-eluting rotational spun coating comprises at least two layers of rotational spun fibers having a diameter of between about 50 nanometers and about 3 micrometers, and wherein the drug-eluting rotational spun coating has a percent porosity of between about 30% and about 80%.
2. The medical device of claim 1 , wherein the therapeutic agent is selected from at least one of rapamycin, paclitaxel, a bismuth-containing compound, heparin, and analogs of any of the foregoing.
3. The medical device of claim 1 , wherein the rotational spun coating is configured to deliver a dose of a therapeutic agent to a target tissue of between about 100 μg and about 600 μg.
4. The medical device of claim 1 , wherein the drug-eluting rotational spun coating comprises at least one of nylon 6-6, polyethylene, polypropylene, PTFE, and Kevlar.
5. The medical device of claim 1 , wherein the drug-eluting rotational spun coating comprises at least one of fibrin, fibrinogen, chitin, chitosan, starch, collagen, hyaluronic acid, alginate, dextran, cellulose, and mixtures thereof.
6. The medical device of claim 1 , wherein the drug-eluting rotational spun coating comprises rotational spun fibers between 750 nanometers and 2 microns in diameter.
7. The medical device of claim 1 , wherein the drug-eluting rotational spun coating comprises a percent porosity of between about 40% and about 60%.
8. The medical device of claim 1 , wherein the drug-eluting rotational spun coating comprises at least one layer of a drug-eluting rotational spun material, and at least one layer of a non-drug-eluting rotational spun material.
9. The medical device of claim 1 , further comprising at least one layer of a non-spun material.
10. The medical device of claim 1 , wherein the therapeutic agent is associated with the drug-eluting rotational spun coating via covalent or ionic bonding.
11. The medical device of claim 1 , further comprising an electrospun coating.
12. The medical device of claim 1 , wherein the medical device is selected from at least one of a balloon, a stent, a catheter or a vascular graft.
13. A medical device comprising a drug-eluting rotational spun coating and at least one layer of non-spun material, wherein the drug-eluting rotational spun coating comprises a therapeutic agent in an amount configured to deliver a pharmaceutically effective dose to a target tissue, wherein the drug-eluting rotational spun coating comprises at least two layers of rotational spun fibers having a diameter of between about 50 nanometers and about 3 micrometers, and wherein the drug-eluting rotational spun coating has a percent porosity of between about 30% and about 80%.
14. The medical device of claim 13 , wherein the therapeutic agent is selected from at least one of rapamycin, paclitaxel, a bismuth-containing compound, heparin, and analogs of any of the foregoing.
15. The medical device of claim 13 , wherein the rotational spun coating is configured to deliver a dose of a therapeutic agent to a target tissue of between about 100 μg and about 600 μg.
16. The medical device of claim 13 , wherein the drug-eluting rotational spun coating is configured to provide a controlled release of a therapeutic agent to a target tissue.
17. The medical device of claim 13 , wherein the drug-eluting rotational spun coating comprises at least one of nylon 6-6, polyethylene, polypropylene, PTFE, and Kevlar.
18. The medical device of claim 13 , wherein the drug-eluting rotational spun coating comprises at least one of fibrin, fibrinogen, chitin, chitosan, starch, collagen, hyaluronic acid, alginate, dextran, cellulose, and mixtures thereof.
19. The medical device of claim 13 , wherein the drug-eluting rotational spun coating comprises rotational spun fibers between 750 nanometers and 2 microns in diameter.
20. The medical device of claim 13 , wherein the drug-eluting rotational spun coating comprises a percent porosity of between about 40% and about 60%.
21. The medical device of claim 13 , wherein the drug-eluting rotational spun coating comprises at least one layer of a drug-eluting rotational spun material, and at least one layer of a non-drug-eluting rotational spun material.
22. The medical device of claim 13 , further comprising an electrospun coating.
23. The medical device of claim 13 , wherein the medical device is selected from at least one of a balloon, a stent, a catheter or a vascular graft.
24. A medical device comprising a drug-eluting rotational spun coating, wherein the drug-eluting rotational spun coating comprises a therapeutic agent in an amount configured to deliver a pharmaceutically effective dose to a target tissue, wherein the therapeutic agent is associated with the drug-eluting rotational spun coating via covalent or ionic bonding, wherein the drug-eluting rotational spun coating comprises at least two layers of rotational spun fibers having a diameter of between about 50 nanometers and about 3 micrometers, and wherein the drug-eluting rotational spun coating has a percent porosity of between about 30% and about 80%.
25. The medical device of claim 24 , wherein the therapeutic agent is selected from at least one of rapamycin, paclitaxel, a bismuth-containing compound, heparin, and analogs of any of the foregoing.
26. The medical device of claim 24 , wherein the rotational spun coating is configured to deliver a dose of a therapeutic agent to a target tissue of between about 100 μg and about 600 μg.
27. The medical device of claim 24 , wherein the drug-eluting rotational spun coating comprises at least one of nylon 6-6, polyethylene, polypropylene, PTFE, and Kevlar.
28. The medical device of claim 24 , wherein the drug-eluting rotational spun coating comprises at least one of fibrin, fibrinogen, chitin, chitosan, starch, collagen, hyaluronic acid, alginate, dextran, cellulose, and mixtures thereof.
29. The medical device of claim 24 , wherein the drug-eluting rotational spun coating comprises rotational spun fibers between 750 nanometers and 2 microns in diameter.
30. The medical device of claim 24 , wherein the drug-eluting rotational spun coating comprises a percent porosity of between about 40% and about 60%.
31. The medical device of claim 24 , wherein the drug-eluting rotational spun coating comprises at least one layer of a drug-eluting rotational spun material, and at least one layer of a non-drug-eluting rotational spun material.
32. The medical device of claim 24 , further comprising an electrospun coating.
33. The medical device of claim 24 , wherein the medical device is selected from at least one of a balloon, a stent, a catheter or a vascular graft.