Treating cancer using electromagnetic fields in combination with photodynamic therapy
View Patent ↗A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.
1. An apparatus for simultaneously exposing a target region within a subject's body to light and an electric field, the subject's body having an internal resistance, the apparatus comprising:
at least two electrodes configured so that when the at least two electrodes are applied to a surface of the subject's body and driven by an AC voltage source, an AC electric field is capacitively coupled into the target region within the subject's body;
an AC waveform generator operatively connected to the at least two electrodes, the AC waveform generator having a frequency between about 50 kHz and about 500 kHz; and
a light-emitting assembly that is adapted for implantation within the subject's body, the light-emitting assembly having a first terminal and a second terminal, wherein the light-emitting assembly has a forward resistance that is significantly larger than the internal resistance of the subject's body, and wherein the light-emitting assembly is configured to emit light when the first terminal and the second terminal are positioned with respect to the AC electric field so that an AC voltage gradient of 2 V or more appears between the first terminal and the second terminal.
2. The apparatus of claim 1 , wherein the light-emitting assembly comprises a light-emitting diode.
3. The apparatus of claim 1 , wherein the first terminal and the second terminal are spaced apart by a distance of between 0.5 and 5 cm.
4. The apparatus of claim 1 , wherein a surface of the at least two electrodes that contacts the subject's body is insulated.
5. The apparatus of claim 1 , wherein the light-emitting assembly comprises a plurality of light-emitting diodes wired in parallel.
6. The apparatus of claim 1 , wherein the AC waveform generator has a frequency between 100 and 500 kHz.
7. The apparatus of claim 1 , wherein the AC electric field has an intensity between 1 and 10 V/cm in the target region.
8. The apparatus of claim 7 , wherein the first terminal and the second terminal are spaced apart by a distance of 2 cm or more.
9. The apparatus of claim 1 , wherein the first terminal and the second terminal are spaced apart by a distance of 2 cm or more.