Azepino[4,5-B]indoles and methods of use

1. A compound of formula (I):

where:

R 1 is H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C 1 -C 8 alkyl, substituted or unsubstituted C 2 -C 8 alkenyl, substituted or unsubstituted C 2 -C 8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C 1 -C 8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, alkylsulfonylamino, or carbonylalkylenealkoxy;

each R 2a , R 2b , R 3a and R 3b is independently H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C 1 -C 8 alkyl, substituted or unsubstituted C 2 -C 8 alkenyl, substituted or unsubstituted C 2 -C 8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C 1 -C 8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, alkylsulfonylamino, or carbonylalkylenealkoxy, or is taken together with the carbon to which it is attached and a geminal R 2 or R 3 to form a cycloalkyl moiety or a carbonyl moiety;

each R 10a , R 10b , R 11a and R 11b is independently H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C 1 -C 8 alkyl, substituted or unsubstituted C 2 -C 8 alkenyl, substituted or unsubstituted C 2 -C 8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C 1 -C 8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, alkylsulfonylamino, or carbonylalkylenealkoxy, or is taken together with the carbon to which it is attached and a geminal R 10 or R 11 to form a cycloalkyl moiety or a carbonyl moiety;

each X 7 , X 8 , X 9 and X 10 is independently CR 4 ;

each R 4 is independently H, hydroxyl, nitro, cyano, halo, C 1 -C 8 perhaloalkyl, substituted or unsubstituted C 1 -C 8 alkyl, substituted or unsubstituted C 2 -C 8 alkenyl, substituted or unsubstituted C 2 -C 8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C 1 -C 8 perhaloalkoxy, C 1 -C 8 alkoxy, aryloxy, carboxyl, carbonylalkoxy, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;

each m and q is independently 0 or 1;

each R 8a , R 8b , R 8c , R 8d , R 8e and R 8f is independently H, hydroxyl, alkoxy, halo, C 1 -C 8 perhaloalkyl, carboxy, carbonylalkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 1 -C 8 alkyl, substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted C 2 -C 8 alkenyl, or is taken together with a geminal R 8 to form a moiety of the formula —OCH 2 CH 2 O—, is taken together with the carbon to which it is attached and a geminal R 8 to form a cycloalkyl moiety or a carbonyl moiety, is taken together with a geminal R 8 to form a methylene or a substituted methylene, is taken together with a vicinal R 8 and the carbon atoms to which they are attached to form a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 3 -C 8 cycloalkenyl or substituted or unsubstituted heterocyclyl moiety or is taken together with a vicinal R 8 to form a bond, provided (i) when an R 8 is taken together with a vicinal R 8 to form a bond, the geminal R 8 is other than hydroxyl, and (ii) at least one of R 8a , R 8b , R 8c , R 8d , R 8e and R 8f is hydroxyl; and

Q is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted amino, alkoxy, aminoacyl, acyloxy, carbonylalkoxy, aminocarbonylalkoxy, acylamino, carboxy, cyano or alkynyl;

or a salt or solvate thereof.

2. The compound of claim 1 , wherein each R 4 is independently H, halo, unsubstituted C 1 -C 4 alkyl, C 1 -C 4 perhaloalkyl or substituted or unsubstituted aryl.

3. The compound of claim 1 , wherein R 1 is H, substituted or unsubstituted C 1 -C 8 alkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted aralkyl.

4. The compound of claim 1 , wherein R 1 is methyl, ethyl, cyclopropyl, propylate, trifluoromethyl, isopropyl, tert-butyl, sec-butyl, 2-methylbutyl, propanal, 1-methyl-2-hydroxyethyl, 2-hydroxyethanal, 2-hydroxyethyl, 2-hydroxypropyl, 2-hydroxy-2-methylpropyl, cyclobutyl, cyclopentyl, cyclohexyl, substituted phenyl, piperidin-4-yl, hydroxycyclopent-3-yl, hydroxycyclopent-2-yl, hydroxycycloprop-2-yl, 1-hydroxy-1-methylcycloprop-2-yl, or 1-hydroxy-1,2,2-trimethyl-cycloprop-3-yl.

5. The compound of claim 1 , wherein:

each R 2a and R 2b is independently H, unsubstituted C 1 -C 8 alkyl, or halo, or R 2a and R 2b are taken together with the carbon to which they are attached to form a carbonyl moiety; and

each R 3a and R 3b is independently H, unsubstituted C 1 -C 8 alkyl, or halo, or R 3a and R 3b are taken together with the carbon to which they are attached to form a carbonyl moiety.

6. The compound of claim 5 , wherein each of R 2a , R 2b , R 3a and R 3b is H.

7. The compound of claim 1 , wherein each R 10a , R 10b , R 11a and R 11b is independently H, bromo, methyl, or hydroxyl, or R 10a and R 10b are taken together with the carbon to which they are attached to form a carbonyl, or R 11a and R 11b are taken together with the carbon to which they are attached to form a carbonyl.

8. The compound of claim 1 , wherein each R 8a , R 8b , R 8c , R 8d , R 8e and R 8f is independently H, hydroxyl, or unsubstituted C 1 -C 4 alkyl, or is taken together with the carbon to which it is attached and a geminal R 8 to form a cycloalkyl moiety.

9. The compound of claim 1 , wherein at least one of R 8a , R 8b , R 8c , R 8d , R 8e and R 8f is taken together with the carbon to which it is attached and a geminal R 8 to form a methylene or a substituted methylene.

10. The compound of claim 1 , wherein at least one of R 8a , R 8b , R 8c , R 8d , R 8e and R 8f is taken together with a vicinal R 8 to form a bond.

11. The compound of claim 1 , wherein q is 0 and m is 0 or 1.

12. The compound of claim 1 , wherein:

R 1 is substituted or unsubstituted C 1 -C 8 alkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted aryl;

each R 2a and R 2b is independently H, methyl, or fluoro, or R 2a and R 2b are taken together with the carbon to which they are attached to form a carbonyl moiety;

each R 3a and R 3b is independently H or fluoro;

each R 10a and R 10b is independently H, fluoro or methyl, or R 10a and R 10b are taken together with the carbon to which they are attached to form a carbonyl; and

each R 11a and R 11b is independently H, fluoro or methyl, or R 11a and R 11b are taken together with the carbon to which they are attached to form a carbonyl.

13. The compound of claim 1 , wherein Q is substituted or unsubstituted amino, alkoxy, aminoacyl, acyloxy, carbonylalkoxy, aminocarbonylalkoxy or acylamino.

14. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

15. A kit comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.

16. The compound of claim 1 wherein the compound is selected from the group consisting of compounds J-2, J-13, J-14, J-15, J-18, J-23, J-25, and J-27:

or a salt thereof.