IP Library Granted Patent US 9,216,066
Granted Patent B2
US 9,216,066 · App. 13/792,931 · Granted Dec 22, 2015

System and method for creating a customized anatomical model of an eye

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Quick Facts
Patent No.
US 9,216,066
App. No.
13/792,931
Granted
Dec 22, 2015
Kind
B2
Abstract

A system and method for creating a line recognition template that replicates an object is provided for use as a control reference during ophthalmic surgery on the object. Creation of the template first requires aligning a plurality of reference points along a central “z” axis, with anatomically measured lengths (Δ“z” n ) between adjacent reference points. Axially-symmetric surfaces can then be traced between selected, adjacent, reference points to create the template. For the present invention, the location of reference points, and the tracing of axially-symmetric surfaces, are based on a cross sectional image of the object for surgery. Preferably, the cross sectional image is obtained using Optical Coherence Tomography (OCT) techniques.

Claims (41)

1. A method for creating a line recognition template to replicate an object which comprises the steps of:

aligning a plurality of reference points along a linear axis;

establishing a base reference axis, wherein the base reference axis is oriented in a “z” direction;

locating a base reference point on the base reference axis, wherein the base reference point is on an interface surface inside the object;

tracing a circular path on the interface surface, wherein the path is at a distance “r” from the base reference axis;

measuring variations in “z” along the path relative to a rotation angle (θ) about the base reference axis to identify a differential (δ z ), wherein δ z is measured between a z max at θ 1 and a z min at θ 2 ;

using δ z , θ 1 and θ 2 to measure an angle of tilt (φ) for the linear axis;

locating the reference points on the linear axis with anatomically measured contiguous lengths (Δ“z” n ) along the linear axis between sequentially adjacent reference points; and

tracing an axially-symmetric surface from selected reference points to create the template for replicating the object.

2. A method as recited in claim 1 wherein the locating step and the tracing step are based on a cross sectional image of the object.

3. A method as recited in claim 2 wherein the cross sectional image is obtained using techniques selected from a group comprising Optical Coherence Tomography (OCT), Scheimpflug, two-photon imaging and range finding.

4. A method as recited in claim 1 further comprises the steps of:

identifying a first axis, wherein the first axis is substantially parallel to the base reference axis and is at a distance “d 1 ” from the base reference axis;

locating a first reference point on the first axis, wherein the first reference point is located on the interface surface;

comparing the location of the first reference point with an expected location for the first reference point to determine a first differential (δ z ′);

identifying a second axis, wherein the second axis is substantially parallel to the base reference axis and is at a distance “d 2 ” from the base reference axis;

locating a second reference point on the second axis, wherein the second reference point is on the interface surface;

comparing the location of the second reference point with an expected location for the second reference point to determine a second differential (δ z ″); and

using δ z ′ and δ z ″ to measure verify the angle of tilt (φ).

5. A method as recited in claim 1 further comprising the step of using at least one selected reference point, together with the axis, as a base reference for controlling a movement of a laser beam focal point relative to the axially-symmetric surface.

6. A method as recited in claim 5 wherein a first reference point is located on a posterior surface of an anterior capsule and a second reference point is located on an anterior surface of a posterior capsule, and the focal point of the laser beam is moved between the anterior capsule and the posterior capsule to perform a capsulotomy.

7. A method for replicating anatomical features inside an eye which comprises the steps of:

identifying a “z” axis for the eye;

determining a tilt angle φ for the “z” axis relative to a base reference axis;

locating a base reference point on the base reference axis, wherein the base reference point is on an interface surface inside the object;

tracing a circular path on the interface surface, wherein the path is at a distance “r” from the base reference axis;

measuring variations along the base reference axis relative to a rotation angle (θ) about the base reference axis to identify a differential (δ), wherein δ is measured between a δ max at θ 1 and a δ min at θ 2 ;

using δ, θ 1 and θ 2 to measure the angle of tilt (φ);

creating a cross sectional image of the eye, wherein the image includes the “z” axis;

establishing a plurality of reference points aligned in sequence along the “z” axis in the cross sectional image, wherein each reference point is respectively located where a surface shown in the image intersects the “z” axis;

relating each reference point to a particularly identified anatomical surface in the image;

measuring a plurality of contiguous lengths (Δ“z” n ) along the “z” axis, wherein each length is individually measured between sequentially adjacent reference points; and

tracing an axially-symmetric surface from selected reference points to create a template replicating anatomical features inside the eye.

8. A method as recited in claim 7 wherein the creating step is accomplished using an Optical Coherence Tomography (OCT) device.

9. A method as recited in claim 7 further comprising the step of tracing a replica of an anatomical surface, wherein the replica is based on the location of a selected reference point and information in the image.

10. A method as recited in claim 7 further comprising the step of using at least one selected reference point, together with the “z” axis, as a base reference for controlling a movement of a laser beam focal point relative to an identified surface.

11. A method as recited in claim 10 wherein a first reference point is located on a posterior surface of an anterior capsule and a second reference point is located on an anterior surface of a posterior capsule, and the focal point of the laser beam is moved between the anterior capsule and the posterior capsule to perform a capsulotomy.

12. A non-transitory, computer-readable medium having executable instructions stored thereon for use with a computer to create a line recognition template to replicate an object, the instructions comprising: aligning a plurality of reference points in sequence along a linear axis; establishing a base reference axis oriented in a “z” direction and locating a base reference point on the base reference axis at an interface surface inside the object; tracing a circular path on the interface surface at a distance “r” from the base reference axis, and measuring variations in “z” along the path relative to a rotation angle (θ) about the base reference axis to identify a differential (δ z ), wherein δ z is measured between a z max at θ 1 and a z min at θ 2 and using δ z , θ 1 and θ 2 to measure an angle of tilt (φ) for the linear axis; locating the aligned reference points with measured contiguous lengths (Δ“z” n ) along the axis between sequentially adjacent reference points; and tracing an axially-symmetric surface from selected reference points for creating the template to replicate the object.

13. A medium as recited in claim 12 further comprising instructions for using at least one selected reference point, together with the axis, as a base reference for controlling a movement of a laser beam focal point relative to the axially-symmetric surface.

14. A medium as recited in claim 13 wherein a first reference point is located on a posterior surface of an anterior capsule and a second reference point is located on an anterior surface of a posterior capsule, and the focal point of the laser beam is moved between the anterior capsule and the posterior capsule to perform a capsulotomy.

15. A medium as recited in claim 12 wherein the program sections for locating and tracing are based on a cross sectional image of the object and the image is obtained using Optical Coherence Tomography (OCT) techniques.

Assignments (24)
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
Reel/Frame 073637/0001 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
Reel/Frame 073637/0126 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
Reel/Frame 073654/0242 →
ASSIGNMENT OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (059913/0548) Recorded Aug 14, 2025
From: CITIBANK, N.A., AS RESIGNING AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 072469/0091 →
PATENT SECURITY AGREEMENT Recorded Jul 1, 2025
From: BAUSCH & LOMB INCORPORATED; ALDEN OPTICAL LABORATORIES, INC.; BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 071773/0871 →
PATENT SECURITY AGREEMENT Recorded Oct 4, 2023
From: BAUSCH & LOMB INCORPORATED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 065120/0086 →
OMNIBUS PATENT SECURITY RELEASE AGREEMENT (REEL/FRAME 059121/0001) Recorded Nov 2, 2022
From: THE BANK OF NEW YORK MELLON
To: BAUSCH & LOMB INCORPORATED
Reel/Frame 061873/0001 →
OMNIBUS PATENT SECURITY RELEASE AGREEMENT (REEL/FRAME 043251/0932) Recorded Nov 2, 2022
From: THE BANK OF NEW YORK MELLON
To: BAUSCH & LOMB INCORPORATED; TECHNOLAS PERFECT VISION GMBH
Reel/Frame 061872/0099 →
OMNIBUS PATENT SECURITY RELEASE AGREEMENT (REEL/FRAME 045444/0634) Recorded Nov 2, 2022
From: THE BANK OF NEW YORK MELLON
To: BAUSCH & LOMB INCORPORATED; LABORATOIRE CHAUVIN S.A.S.; TECHNOLAS PERFECT VISION GMBH; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 061872/0295 →
OMNIBUS PATENT SECURITY RELEASE AGREEMENT (REEL/FRAME 048556/0758) Recorded Nov 2, 2022
From: THE BANK OF NEW YORK MELLON
To: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH COMPANIES INC.; TECHNOLAS PERFECT VISION GMBH; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 061872/0484 →
OMNIBUS PATENT SECURITY RELEASE AGREEMENT (REEL/FRAME 056811/0814) Recorded Nov 2, 2022
From: THE BANK OF NEW YORK MELLON
To: BAUSCH & LOMB INCORPORATED
Reel/Frame 061872/0669 →
RELEASE OF SECURITY INTEREST IN SPECIFIED PATENTS (REEL/FRAME 045444/0299) Recorded Oct 26, 2022
From: BARCLAYS BANK PLC
To: BAUSCH & LOMB INCORPORATED; TECHNOLAS PERFECT VISION GMBH; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; PF CONSUMER HEALTHCARE 1 LLC; LABORATOIRE CHAUVIN S.A.S.
Reel/Frame 061779/0001 →
RELEASE OF SECURITY INTEREST IN SPECIFIED PATENTS (REEL/FRAME 036400/0711) Recorded Oct 26, 2022
From: BARCLAYS BANK PLC
To: BAUSCH & LOMB INCORPORATED; TECHNOLAS PERFECT VISION GMBH
Reel/Frame 061775/0826 →
PATENT SECURITY AGREEMENT Recorded May 10, 2022
From: BAUSCH & LOMB INCORPORATED
To: CITIBANK, N.A. AS COLLATERAL AGENT
Reel/Frame 059913/0548 →
SECURITY AGREEMENT Recorded Feb 10, 2022
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 059121/0001 →
SECURITY INTEREST Recorded Jun 8, 2021
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 056811/0814 →
SECURITY INTEREST Recorded Mar 11, 2019
From: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 048556/0758 →
SECURITY INTEREST Recorded Feb 26, 2018
From: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
To: THE BANK OF NEW YORK MELLON, AS COLLATERAL AGENT
Reel/Frame 045444/0634 →
SECURITY INTEREST Recorded Feb 26, 2018
From: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 045444/0299 →
SECURITY INTEREST Recorded Jul 19, 2017
From: BAUSCH & LOMB INCORPORATED
To: THE BANK OF NEW YORK MELLON
Reel/Frame 043251/0932 →
SECURITY AGREEMENT Recorded Aug 20, 2015
From: TECHNOLAS PERFECT VISION GMBH; DR. GERHARD MANN CHEM-PHARM. FABRIK GMBH
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 036400/0711 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2013
From: MORDAUNT, DAVID HAYDN
To: BAUSCH & LOMB INCORPORATED
Reel/Frame 030814/0912 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2013
From: MORDAUNT, DAVID HAYDN
To: BAUSCH & LOMB INCORPORATED
Reel/Frame 030815/0103 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 12, 2013
From: SCHLUETER, HOLGER; LOESEL, FRIEDER
To: TECHNOLAS PERFECT VISION GMBH
Reel/Frame 030593/0928 →