Chimeric adenoviruses for use in cancer treatment
View Patent ↗The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
1. Chimeric adenovirus deposited with the American Type Culture Collection on Feb. 25, 2013 under Accession number PTA-13561.
2. A pharmaceutical composition comprising the chimeric adenovirus of claim 1 and a pharmaceutically acceptable excipient.
3. A method of inhibiting growth of a cancer cell, comprising infecting said cancer cell with the chimeric adenovirus of claim 1 .
4. The method of claim 3 , wherein said cancer cell is a colon cancer cell.