MODIFIABLE OCCLUSION DEVICE
An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a pre-established pore features and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material associated with the pore features which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.
1 . An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, comprising:
a structure having pre-established pore features and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel; and
a frangible material associated with the pore features to generate a first condition for the pore features which initially provides a substantial barrier to flow through the frangible material and, for at least a majority of the pore features, is capable of at least one of localized rupturing and localized eroding, in the presence of a localized pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel to generate, within an acute time period, a second condition for pore features experiencing the localized pressure differential to minimize ischemia downstream of the perforator vessel.
2 . The occlusive device of claim 1 wherein the structure includes metallic struts.
3 . The occlusive device of claim 1 wherein the frangible material includes a thin film.
4 . The occlusive device of claim 3 wherein the film is formed of at least one of cellulose, alginate, urethane, polycaprolactone and polyglycolic acid.
5 . The occlusive device of claim 1 wherein at least a substantial amount of the surface area of the frangible material defines openings at least 10 microns in diameter prior to implantation in the patient.
6 . The occlusive device of claim 1 wherein the frangible material has a thickness ranging between 10 microns to 500 microns prior to implantation in the patient.
7 . The occlusive device of claim 1 wherein at least some of the pore features have geometries that differ from the geometries of other of the pore features.
8 . The occlusive device of claim 1 wherein the pore features are regularly spaced along the length of the structure.
9 . The occlusive device of claim 1 wherein the frangible material includes at least one biodegradable composition.
10 . The occlusive device of claim 1 wherein the structure includes a porous foam having a porosity which defines the pore features.
11 . The occlusive device of claim 10 wherein the frangible material includes at least one biodegradable composition interspersed through at least a portion of the porosity of the foam.
12 . The occlusive device of claim 10 wherein the foam includes porous urethane.
13 . The occlusive device of claim 12 wherein the biodegradable material includes polycaprolactone.
14 . The occlusive device of claim 1 wherein the frangible material is capable of responding to a pressure differential equivalent to one to fifty mm Hg.
15 . The occlusive device of claim 1 wherein the acute time period is less than ten minutes.
16 . A method of treating an aneurysm in a parent vessel in a patient, comprising:
selecting an occlusive device including a structure having pre-established pore features and having dimensions suitable for insertion into vasculature of the patient, and including a frangible material associated with the pore features to generate a first condition for the pore features which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a localized pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel to generate, within an acute time period, a second condition for pore features experiencing the localized pressure differential to minimize ischemia downstream of the perforator vessel;
inserting the occlusive device into vasculature of the patient to reach the region of the aneurysm in the parent vessel; and
positioning the occlusive device to occlude flow into the aneurysm.
17 . The method of claim 16 wherein the structure includes metallic struts.
18 . The method of claim 16 wherein the frangible material includes a thin film.
19 . The method of claim 16 wherein at least a substantial amount of the surface area of the frangible material defines openings at least 10 microns in diameter prior to implantation in the patient.
20 . The method of claim 16 wherein at least some of the pore features have geometries that differ from the geometries of other of the pore features.
21 . The method of claim 16 wherein the frangible material includes at least one biodegradable composition.
22 . The method of claim 16 wherein the structure includes a porous foam having a porosity which defines the pore features.
23 . The method of claim 22 wherein the frangible material includes at least one biodegradable composition interspersed through at least a portion of the porosity of the foam.
24 . The method of claim 16 wherein the frangible material is capable of responding to a pressure differential equivalent to one to fifty mm Hg.
25 . The method of claim 16 wherein the acute time period is less than ten minutes.
26 . The method of claim 16 wherein the frangible material has a thickness ranging between 10 microns to 500 microns prior to implantation in the patient.
27 . An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, comprising:
a structure having pre-established pore features and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel; and
biodegradable material interspersed through at least a majority of the pore features which initially provides a substantial barrier to flow through the biodegradable material and being capable of at least localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.
28 . The occlusive device of claim 27 wherein at least a substantial amount of the surface area of the biodegradable material defines openings at least 10 microns in diameter prior to implantation in the patient.
29 . The occlusive device of claim 27 wherein the structure includes a substantially non-biodegradable porous foam defining the pore features through which the biodegradable material is dispersed.
30 . The occlusive device of claim 29 wherein the foam has a thickness ranging between 10 microns to 500 microns prior to implantation in the patient.
31 . The occlusive device of claim 29 wherein the pore features of the foam defines pores having an average diameter ranging between 50 microns to 500 microns.