Injectable hydrogels
View Patent ↗Described herein are methods of forming hydrogels comprising combining (a) a water-soluble polymer comprising thiol groups, and (b) a water-soluble metal salt in an aqueous solution. The hydrogels form rapidly. Hydrogels and related methods, uses, and products also are described.
1. A method for producing a hydrogel, comprising combining
(a) a first aqueous solution comprising from about 1 wt % to about 20 wt % water-soluble polymer, based on the weight of the first aqueous solution, wherein the water-soluble polymer comprises thiol groups, and wherein the molecular weight of the water-soluble polymer is about 10,000 g/mol or more, and
(b) a second aqueous solution comprising from about 0.05 wt % to about 20 wt % water-soluble AuCl 3 ,
wherein the molar ratio of the thiol groups of the water-soluble polymer in the first aqueous solution to gold atoms of the AuCl 3 in the second aqueous solution is from about 1:1 to about 5:1, and the volume ratio of the first aqueous solution to the second aqueous solution is from about 2:1 to about 4:1;
thereby forming a hydrogel, wherein the hydrogel forms in five seconds or less.
2. The method of claim 1 , wherein the water-soluble polymer comprises a polymer backbone and one or more branches and substituents.
3. The method of claim 2 , wherein one or more of the backbone, the branches, or the substituents comprise a thiol group.
4. The method of claim 3 , wherein the thiol group is attached at an end-cap position on one or more of the backbone, the branches, or the substituents.
5. The method of claim 1 , wherein the water-soluble polymer comprises a polymer selected from the group consisting of polysaccharide; gelatin; cellulose; starch; lipids; albumin; collagen; polylysine; polyvinyl alcohol; polyvinyl pyrrolidone; polyethylene glycol; polypropylene glycol; polyacrylic compounds; methacrylic compounds; polyethylene imines; polysiloxane; polyacrylamides; polyethylene oxide; poly(2-acrylamido-2-methyl-1-propanesulfonic acid); copolymers of any of the foregoing; oligomers of lactic acid, glycolic acid, paradioxanone, caprolactone, trimethylene carbonate, or co-oligomers thereof; oligomeric esters; small molecules; and combinations of two or more thereof.
6. The method of claim 5 , wherein the water-soluble polymer comprises a polyethylene glycol comprising at least 4 branches.
7. The method of claim 1 , wherein the hydrogel is biodegradable.
8. The method of claim 1 , wherein the water-soluble polymer comprises a polymer backbone.