Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7

1. Method for the preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid (Compound ‘A’), comprising steps:

a) reacting 10-(tert-butoxycarbonyl)-13-cyclohexyl-3-methoxy-7H-indolo-[2,1-a]-[2]-benzazepine-6-carboxylic acid (Compound I) with tert-butyl (methyl-{2-[2-(methylamino)-ethoxy]-ethyl}-sulphamoyl)-carbamate (Compound ‘B’) in the presence of a coupling agent in a suitable solvent, and

b) hydrolysing Compound (II) thus obtained with an acid, so that Compound ‘A’ is obtained

2. Method of claim 1 , where steps a) and b) are carried out as a one-vessel synthesis.

3. Method of claim 1 , where the coupling agent is selected from the group consisting of: carbodiimidazole (CDI), dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazole-1-yl)-1, 1, 3 ,3 -tetramethyluronium hexafluorophosphate (HATU), bromotri-(pyrrolidino)-phosphonium hexafluorophosphate (PyBrOP), and a combination of 1-hydroxybenztriazole hydrate (HOBT.H 2 O) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDCI).

4. Method of claim 1 , where the acid used in step b) is selected from the group consisting of trifluoroacetic acid, methanesulphonic acid, hydrogen chloride, hydrogen bromide, para-toluenesulphonic acid, sulphuric acid and phosphoric acid.

5. Method according to of claim 1 , where the preparation is carried out in a nitrogen atmosphere.

6. Method of claim 5 , where the solvent used in step a) is 2-methyltetrahydrofuran.

7. Method of claim 6 , where the organic acid used in step b) is methanesulphonic acid, the reaction temperature is 50° C., and the duration of the reaction is no longer than 5 hours.