TUMOR PROLIFERATION INHIBITOR CONTAINING ULTRASOUND-SENSITIVE SUBSTANCE AND METHOD FOR INHIBITING TUMOR PROLIFERATION BY USING TUMOR PROLIFERATION INHIBITOR AND LOW-INTENSITY PULSED ULTRASOUND WAVES
Provided are a tumor proliferation inhibitor and a method for inhibiting tumor proliferation both of which can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound. The present invention provides a tumor proliferation inhibitor containing an ultrasound-sensitive substance and an acoustic cavitation phenomenon-enhancing substance, and provides a method for inhibiting tumor proliferation that can exhibit a tumor proliferation-inhibitory effect using the tumor proliferation inhibitor in combination with low-intensity pulsed ultrasound of a degree that is used in ultrasound diagnosis, and that can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound.
1 - 6 . (canceled)
7 . A tumor proliferation inhibitor containing an ultrasound-sensitive substance substantially unreactive with a light and an acoustic cavitation phenomenon-enhancing substance.
8 . The tumor proliferation inhibitor as claimed in claim 7 , wherein said ultrasound-sensitive substance is a porphyrin derivative or a xanthene derivative.
9 . The tumor proliferation inhibitor as claimed in claim 8 , wherein said porphyrin derivative is [7,12-bis(1-(2-(2-hydroxyethoxy)ethoxy)ethyl)-3,8,13, 17-tetramethyl-porphyrin-2,18-dipropionato]manganese (DEG) as represented by formula [I]:
or 3,17-bis(1-carboxyethyl)-8-[2-(2,4-dichlorophenyl-hydrazono) ethylidene]-3-ethenyl-7-hydroxy-2,7,12,18-tetramethylchlorin disodium salt as represented by formula [II]:
10 . The tumor proliferation inhibitor as claimed in claim 7 , wherein said acoustic cavitation phenomenon-enhancing substance is gas-filled bubbles.
11 . The tumor proliferation inhibitor as claimed in claim 10 , wherein said gas-filled bubbles are microbubbles or nanobubbles.
12 . The tumor proliferation inhibitor as claimed in claim 10 , wherein said gas-filled bubbles are sonazoid or levovist.
13 . A method for the treatment of cancers using a tumor proliferation inhibitor containing an ultrasound-sensitive substance substantially unreactive with a light and an acoustic cavitation phenomenon-enhancing substance.
14 . The method as claimed in claim 13 , wherein said ultrasound-sensitive substance is a porphyrin derivative or a xanthene derivative.
15 . The method as claimed in claim 14 , wherein said porphyrin derivative is [7,12-bis(1-(2-(2-hydroxyethoxy)ethoxy)ethyl)-3,8,13,17-tetramethylporphyrin-2, 18-dipropionato]manganese (DEG) as represented by formula [I]:
or 3,17-bis(1-carboxyethyl)-8-[2-(2,4-dichlorophenyl-hydrazono) ethylidene]-3-ethenyl-7-hydroxy-2,7,12,18-tetramethylchlorin disodium salt as represented by formula [II]:
16 . The method as claimed in claim 13 , wherein said acoustic cavitation phenomenon-enhancing substance is gas-filled bubbles.
17 . The method as claimed in claim 16 , wherein said gas-filled bubbles are microbubbles or nanobubbles.
18 . The method as claimed in claim 16 , wherein said gas-filled bubbles are sonazoid or levovist.