Fused heterocyclic ring compound
Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
1. A compound represented by the formula (I):
wherein
a partial structural formula:
ring A is a nitrogen-containing fused heterocyclic group optionally substituted with 1 to 5 C 1-6 alkyl groups, wherein nitrogen(s) is/are the only heteroatom(s) in the heterocyclic group,
L 1a is
—X 2 —Y 2 —(X 2 is a bond or —O—; Y 2 is an optionally substituted C 1-6 alkylene group),
R 1 is (1) a C 1-6 alkyl group optionally substituted with 1 to 3 halogen atoms or one C 3-7 cycloalkyl group, (2) a C 3-7 cycloalkyl group, or (3) a C 6-14 aryl group optionally substituted with a C 1-6 alkyl group substituted with 1 to 3 halogen atoms,
R 2 is a hydrogen atom, or a pyrazolyl group optionally substituted with a substituent selected from the group consisting of a C 1-6 alkyl group and a C 6-14 aryl group, and
—R y is a hydrogen atom,
or a salt thereof.
2. 5-[2-(2,3-Dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-1-methyl-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one or a salt thereof.
3. 1-(Cyclopropylmethyl)-5-[3-(1-methyl-1H-benzimidazol-2-yl)propoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one or a salt thereof.
4. 1-(Cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one or a salt thereof.
5. 5-(3-Imidazo[1,2-a]pyridin-2-ylpropoxy)-1-methyl-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one or a salt thereof.
6. 1-Cyclobutyl-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one or a salt thereof.
7. A pharmaceutical composition comprising the compound according to claim 1 or a salt thereof, and a pharmacologically acceptable carrier.
8. The pharmaceutical composition according to claim 7 , which is a phosphodiesterase 10A inhibitor.