Purification process
View Patent ↗A process for purifying Mo-99 from an acidic solution obtained by dissolving an irradiated solid target comprising uranium in an acidic medium, or from an acidic solution comprising uranium and which has previously been irradiated in a nuclear reactor, or from an acidic solution comprising uranium and which has been used as reactor fuel in a homogeneous reactor, the process comprising contacting the acidic solution with an adsorbent comprising a zirconium oxide, zirconium hydroxide, zirconium alkoxide, zirconium halide and/or zirconium oxide halide, and eluting the Mo-99 from the adsorbent using a solution of a strong base, the eluate then being subjected to a subsequent purification process involving an alkaline-based Mo-99 chromatographic recovery step on an anion exchange material. Also provided is apparatus for carrying out the process.
1. A process for purifying Mo-99 from (i) an acidic solution by dissolving an irradiated solid target comprising uranium in an acidic medium; (ii) an acidic solution comprising uranium and which has previously been irradiated in a nuclear reactor, or (iii) an acidic solution comprising uranium and which has been used as reactor fuel in a homogeneous reactor, the process comprising
(a) adsorbing the Mo-99 in the acidic solution onto an adsorbent comprising a zirconium compound selected from the group consisting of zirconium oxide, zirconium hydroxide, zirconium alkoxide, zirconium halide and zirconium oxide halide and eluting the Mo-99 from the adsorbent using a solution of base;
(b) adsorbing the eluted Mo-99 in the solution of base onto an anion exchange material and eluting the Mo-99 from the anion exchange material using a solution of acid;
(c) adsorbing the eluted Mo-99 in the solution of acid onto a MnO 2 material and dissolving the MnO 2 material bearing the adsorbed Mo-99 with a solution of sulfuric acid containing thiocyanide ions and a reducing agent to form a solution comprising [Mo(SCN) 6 ] 3− ; and
(d) contacting the solution comprising [Mo(SCN) 6 ] 3− with an ion exchange material comprising iminodiacetate groups to adsorb the Mo-99 onto the ion exchange material and eluting the Mo-99 from the ion exchange material using a solution of base.
2. The process of claim 1 , wherein the adsorbent also comprises a titanium oxide and/or silicon oxide.
3. The process of claim 2 , wherein the zirconium compound is present at a concentration of from 5 to 70 mol % of the adsorbent.
4. The process of claim 1 , wherein the adsorbent is in the form of pellets.
5. The process of claim 1 , wherein the acidic solution is contacted with the adsorbent in a column packed with the adsorbent and provided with an inlet and an outlet.
6. The process of claim 5 , wherein, following passage of the acidic solution through the column packed with the adsorbent, the column is flushed with an acid solution and/or rinsed with water.
7. The process of claim 1 , wherein the solution of base used in step (a) is 1 M sodium hydroxide.
8. The process of claim 1 , wherein the solution of acid used in step (b) is 3-4 M nitric acid.
9. The process of claim 1 , wherein the solution of sulfuric acid containing thiocyanide ions used in step (c) comprises 9 M sulfuric acid.
10. The process of claim 1 , wherein the solution of base used in step (d) is 1 M sodium hydroxide.
11. The process of claim 10 , wherein the solution of base further comprises hydrogen peroxide.
12. The process of claim 1 , wherein the Mo-99 eluted from the ion exchange material in step (d) is adsorbed to an anion exchange material and the Mo-99 is eluted from the anion exchange material using a solution of nitric acid.
13. The process of claim 12 , wherein the eluted Mo-99 in the solution of nitric acid is heated until dryness, thereby forming a dried product.
14. The process of claim 13 , wherein the dried product is sublimated at 800° C. to form a sublimated solid.
15. The process of claim 14 , wherein the sublimated solid is solubilized in an alkaline solution.