IP Library › Granted Patent US 9,233,097
Granted Patent B2
US 9,233,097 · App. 13/814,102 · Granted Jan 12, 2016

ST-246 liquid formulations

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Quick Facts
Patent No.
US 9,233,097
App. No.
13/814,102
Granted
Jan 12, 2016
Kind
B2
Abstract

The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.

Claims (5)

1. A liquid pharmaceutical formulation comprising a therapeutically effective amount of ST-246 and hydroxypropyl-β-cyclodextrin and/or sufobutyl-ether-β-cylodextrin, and further comprising one or more pharmaceutically acceptable ingredients.

2. The liquid pharmaceutical formulation of claim 1 , wherein said pharmaceutically acceptable ingredients are selected from the group consisting of carrier, excipient, diluent, additive, filler, lubricant and binder.

3. The liquid pharmaceutical formulation of claim 1 , wherein said hydroxypropyl-β-cyclodextrin is present in amounts from about 20% to about 40% by weight.

4. The liquid pharmaceutical formulation of claim 1 having a pH between about 3 and 10.

5. The liquid pharmaceutical formulation of claim 1 , wherein said hydroxypropyl-β-cyclodextrin has a degree of substitution of between about 4.0 to about 8.0.

Assignments (3)
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY AT REEL/FRAME NO. 40349/0219 Recorded Mar 13, 2020
From: CORTLAND CAPITAL MARKET SERVICES LLC
To: SIGA TECHNOLOGIES, INC.
Reel/Frame 052163/0014 →
SECURITY INTEREST Recorded Nov 16, 2016
From: SIGA TECHNOLOGIES, INC.
To: CORTLAND CAPITAL MARKET SERVICES, LLC
Reel/Frame 040349/0219 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 5, 2013
From: TYAVANAGIMATT, SHANTHAKUMAR R.; STONE, MELIALANI A.C.L.; WEIMERS, WILLIAM; KASI, KRISHNA GOPI; SAMUEL, PETER N.K.; BOLKEN, TOVE' C.; HRUBY, DENNIS E.
To: SIGA TECHNOLOGIES, INC.
Reel/Frame 030158/0860 →