IP Library › Granted Patent US 9,719,064
Granted Patent B2
US 9,719,064 · App. 13/814,235 · Granted Aug 1, 2017

Genomics of actinoplanes utahensis

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Quick Facts
Patent No.
US 9,719,064
App. No.
13/814,235
Granted
Aug 1, 2017
Kind
B2
Abstract

The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type—and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene- and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.

Claims (7922)

1. A mutated comprising DNA the nucleotide sequence of SEQ ID NO.: 16053 and the mutations shown in the Table below:

Position in

Nucleotide in

Mutated

SEQ ID 16053

SEQ ID 16053

Nucleotide

7102

G

A

11919

G

A

12285

G

A

12651

G

A

13511

G

A

46974

C

T

62542

C

T

64957

C

T

65055

C

T

65455

C

T/C

65460

C

T

65882

G

A

72685

A

A/G

72693

A

A/G

72701

A

A/G

73373

C

T

73467

C

T

76845

C

T

78965

C

T

80653

G

A

85503

G

A

88269

G

A

88369

G

A

89368

C

T

89901

C

T

90029

C

T

91949

C

T

93427

C

T

101351

G

A

103967

C

T

104063

C

T

110857

C

T

112637

G

A

114499

G

A

115250

G

A

115873

C

T

115983

C

T

117494

C

T

119344

G

A

134489

C

T

139515

C

T

146767

C

T

161035

G

A

172303

G

A

176176

G

A

178880

G

G/A

180754

C

T

180925

C

T

184674

G

A

190568

C

T

190644

C

T

191971

C

T

193584

G

A

196028

C

T

196338

C

T

214992

G

A

222841

G

A

222924

C

T

228543

C

T

247200

C

T

248952

C

T

253299

G

A

254551

G

A

259829

C

T

268705

C

T

270822

G

A

273723

G

A

276430

C

T

276561

C

T

283007

G

A

283062

G

A

287132

C

T

294767

G

A

295356

C

T

300028

C

T

303810

G

A

313837

C

T

316698

G

A

316929

G

A

325503

C

T

331088

G

A

340040

G

A

342987

G

A

343915

G

A

352688

C

T

353668

G

A

361019

G

A

362742

G

A

375835

C

T

381358

G

A

382029

G

A

391677

C

T

400166

C

T

406413

G

A

409544

G

A

416199

G

A

419938

C

T

425067

G

A

425419

G

A

426464

G

A

438324

C

T

446368

G

A

446984

G

A

447392

G

A

450492

G

A

458678

C

T

459753

C

T

459833

A

G

466505

G

A

474923

G

A

482599

G

A

494993

G

A

500358

C

T

510408

C

T

511515

G

A

512816

G

A

513902

C

T

515197

G

A

518156

G

A

533618

G

A

536327

C

T

542891

G

A

548989

C

T

553081

G

A

553332

G

A

557884

G

A

557907

C

A

567026

C

T

587166

A

G

590721

G

A

602225

C

T

604184

C

T

605918

C

T

621774

C

T

624361

C

T

625600

C

T

626283

G

A

629283

G

A

636108

C

T

648981

G

A

684062

Ci

A

702171

C

T

702650

C

T

703452

C

T

706109

C

T

711168

G

A

712462

A

A/G

714678

G

A

714785

G

A

717602

G

A

719600

G

A

724097

G

A

738525

C

T

744594

G

A

746362

G

A

750285

C

T

752663

G

A

763762

C

C/G

763785

G

G/C

763792

C

C/G

763951

C

C/G

765635

G

A

766073

G

A

769289

G

A

776043

C

T

780677

C

T

781916

C

T

783900

C

T

786653

G

A

795572

C

T

796824

G

A

798663

G

A

810530

G

A

810533

C

G

810556

T

T/C

810557

G

G/C

810563

C

C/T

810576

A

A/G

819250

G

A

829153

C

T

830171

C

T

831404

G

A

838352

G

A

842068

G

A

847887

G

A

861775

C

T

870304

G

A

880820

C

T

897424

C

T

907842

G

A

908987

C

T

921289

G

A

941088

G

A

945666

G

A

959932

C

T

964504

G

A

964558

C

T

970334

C

T

972781

C

T

995285

G

A

1004653

C

T

1006503

C

T

1008680

G

A

1009674

G

A

1009813

G

A

1023301

C

T

1028963

G

A

1030345

C

T

1030822

G

A

1037262

G

A

1041811

C

T

1054013

C

T

1055406

C

T

1082623

G

A

1085482

C

T

1085499

C

T

1088995

C

T

1097530

C

T

1107807

T

A

1117905

C

T

1119169

G

A

1120103

G

A

1120852

G

A

1122832

C

T

1123080

C

T

1128153

G

A

1130585

G

A

1145784

C

T

1146897

G

A

1153166

C

T

1163219

C

T

1163309

G

A

1163538

G

A

1169629

C

T

1169882

C

T

1170591

C

T

1172808

C

T

1172940

C

T

1173551

C

T

1179238

C

A

1192548

C

T

1194346

C

T

1194637

G

A

1196403

C

T

1208932

C

T

1221399

C

T

1222202

C

T

1225212

C

T

1242677

G

A

1249095

C

T

1250477

G

A

1255855

C

T

1260719

C

T

1261347

C

T

1261926

C

T

1262307

G

A

1262367

G

A

1267545

C

T

1270664

C

T

1272928

C

T

1273797

C

T

1277491

G

A

1282245

G

A

1284346

C

T

1285883

C

T

1291340

C

T

1300654

G

A

1306705

C

T

1307526

C

T

1308200

C

T

1315876

C

T

1317961

G

A

1321981

C

T

1322304

C

T

1325473

C

T

1325983

G

A

1327837

C

T

1329364

C

T

1330802

G

A

1335338

C

T

1342390

C

T

1343472

A

C

1344261

C

T

1346995

C

T

1348395

G

A

1351344

C

T

1352745

C

T

1356389

C

T

1359105

G

A

1359182

C

T

1362032

C

T

1370065

G

A

1370088

C

T

1379821

C

T

1382638

G

A

1388800

C

T

1404278

C

T

1409508

G

A

1410045

G

A

1413757

G

A

1415711

G

A

1415773

G

A

1418132

C

T

1419671

G

A

1420016

C

T

1428228

C

T

1428233

C

T

1435884

C

T

1438355

C

T

1440872

G

A

1443149

C

T

1450678

G

A

1453590

G

A

1454075

C

T

1455191

G

A

1463521

C

T

1473239

C

T

1474775

G

A

1482297

C

T

1494980

G

A

1502729

G

A

1514463

C

T

1525258

G

A

1533361

C

T

1545597

T

T/C

1563822

C

T

1563854

C

T

1565818

C

T

1566866

C

T

1570236

G

A

1570636

C

T

1581033

T

C

1594972

G

A

1614616

C

T

1615586

C

T

1616152

C

T

1616981

C

T

1617561

C

T

1617928

C

T

1622589

G

A

1641656

C

T

1641711

C

T

1641953

C

T

1648653

G

A

1648676

G

A

1649444

C

T

1650400

G

A

1658589

G

A

1661376

G

A

1664324

C

T

1680524

C

T

1682349

G

A

1682842

C

T

1686608

C

T

1695571

C

T

1699167

G

A

1700705

G

A

1715788

T

C

1727072

G

A

1747963

C

T

1748448

C

T

1778278

C

T

1779396

C

T

1779723

C

T

1792608

G

A

1793069

C

T

1795610

C

T

1803172

C

T

1805902

C

T

1815104

C

T

1848170

G

A

1858054

C

T

1874864

G

A

1878368

C

T

1878456

C

T

1881797

G

A

1881821

G

A

1883780

G

A

1886024

G

A

1886177

G

A

1886499

G

A

1888003

G

A

1888277

G

A

1891012

G

A

1891205

C

T

1891493

G

A

1891608

G

A

1895230

C

T

1896121

G

A

1898465

G

A

1904126

G

A

1904415

G

A

1918600

G

A

1926767

G

A

1930239

G

A

1933689

G

A

1935111

G

A

1938524

G

A

1941158

G

A

1950155

C

T

1961896

C

T

1964247

C

T

1971635

A

C

1973884

G

A

1985968

G

A

1986215

C

T

1987891

C

T

1987907

C

T

1993612

G

A

1997079

C

T

2043866

G

A

2043889

G

A

2048938

C

T

2058063

G

A

2058998

G

A

2060664

G

A

2060796

G

A

2067415

G

A

2067911

G

A

2071535

G

A

2077305

A

G/A

2077309

T

C/T

2077321

A

G/A

2077324

G

A/G

2077336

A

G/A

2077351

C

T/C

2077353

A

G/A

2077369

C

T/C

2077383

G

A/G

2077384

C

G/C

2077398

G

G/C

2077432

T

C/T

2077603

A

G/A

2077615

C

A/C

2077618

G

A/G

2077636

T

C/T

2077645

G

C/G

2077651

G

C/G

2077652

A

G/A

2077654

A

G/A

2077663

C

A/C

2077669

G

C/G

2077671

T

C/T

2077682

C

G/C

2077688

G

A/G

2077691

C

G/C

2077694

A

C/A

2077697

G

C/G

2077703

T

G/T

2077715

G

A/G

2077724

A

G/A

2077726

C

T/C

2077730

G

C/G

2077733

G

A/G

2077736

C

C/T

2077742

G

C/G

2077745

A

G/A

2077751

G

A/G

2077762

T

C/T

2077769

T

C/T

2077772

A

G/A

2077775

G

A/G

2077793

G

C/G

2077794

A

G/A

2077795

C

T/C

2077805

C

T/C

2080486

C

T

2086608

G

A

2096915

G

A

2098836

C

T

2099830

G

A

2126265

C

T

2131730

G

A

2135109

C

T

2136848

C

T

2144528

G

A

2147486

G

A

2154132

C

T

2154136

C

T

2188490

C

T

2191494

C

T

2199567

G

A

2208975

G

A

2212324

G

A

2212659

G

A

2230643

G

A

2235434

G

A

2250499

C

T

2259118

C

T

2260582

G

A

2266821

C

T

2271223

G

A

2273696

C

T

2277990

C

T

2291798

C

T

2293101

C

C/T

2293102

G

G/T

2293121

G

G/C

2293139

A

A/C

2293157

G

G/A

2293169

G

G/C

2293175

G

G/A

2293176

A

A/T

2293184

C

C/G

2293185

G

G/A

2293187

A

A/G

2293196

G

A/G

2293202

G

G/C

2293205

G

C/G

2293214

G

G/C

2293219

A

A/T

2293220

G

G/C

2293226

G

C/G

2293228

G

G/A

2293234

A

A/T

2293235

G

G/C

2293238

G

G/C

2293244

G

G/C

2293247

G

A/G

2293253

G

A/G

2293268

G

C/G

2293310

G

G/A

2293313

G

G/C

2293316

G

G/A

2293319

G

G/A

2293328

G

G/C

2293337

G

G/C

2293346

G

G/C

2293352

C

C/G

2293367

G

G/C

2293376

C

C/G

2293403

C

C/G

2293463

C

C/G

2302130

G

A

2312744

C

T

2313183

G

A

2315988

C

T

2323085

C

T

2329242

C

T

2332081

G

A

2341627

C

T

2347673

C

T

2348681

G

A

2359598

G

A

2362060

A

G

2368326

G

A

2376154

G

A

2380176

C

T

2382542

C

T

2382567

C

T

2382748

C

T

2389975

C

T

2392147

C

T

2396255

G

A

2415101

G

A

2422620

C

T

2437185

G

A

2448470

G

A

2452760

G

A

2456608

C

T

2459347

C

T

2459641

G

A

2460824

C

T

2463427

C

T

2482048

C

T

2482381

G

A

2483453

C

T

2487377

G

A

2489641

G

A

2492054

G

A

2502775

G

A

2515457

G

A

2518872

G

A

2530466

G

A

2532233

G

A

2533237

G

A

2536306

G

A

2538874

G

A

2542087

G

A

2544720

C

T

2553277

G

A

2556662

C

T

2559280

G

A

2562212

G

A

2564253

G

A

2564620

G

A

2566353

G

A

2572994

G

A

2573153

C

T

2575327

G

A

2599645

G

A

2599894

G

A

2601319

G

A

2606340

G

A

2608948

G

A

2610422

C

T

2614778

G

A

2617082

G

A

2618776

C

T

2618805

C

T

2620558

G

A

2626414

A

G

2636037

C

T

2639682

G

A

2642753

G

A

2644984

C

T

2651718

C

T

2652733

C

T

2653074

C

T

2653159

C

T

2653337

G

A

2655271

C

T

2655308

C

T

2657059

C

T

2658261

G

A

2659295

C

T

2663775

C

T

2670944

C

T

2671043

C

T

2672551

C

T

2676880

C

T

2677056

G

A

2677196

C

T

2678066

G

A

2679900

C

T

2686364

C

T

2687028

C

T

2688632

C

T

2694405

G

A

2701281

G

A

2712327

G

A

2720850

C

T

2728435

G

A

2731397

G

A

2735550

G

G/A

2735576

G

G/C

2738768

C

T

2744600

C

T

2748694

C

T

2756873

C

T

2760595

G

A

2762887

G

A

2763137

G

A

2764279

C

T

2766645

C

T

2770562

C

T

2773173

C

T

2774095

G

A

2774734

G

A

2774874

G

A

2776314

C

T

2776919

C

T

2778598

G

A

2779539

G

A

2782696

C

T

2783578

C

T

2783738

C

T

2785372

C

T

2785531

C

T

2787379

G

A

2788015

C

T

2788247

C

T

2789216

C

T

2790626

C

T

2791577

C

T

2792510

C

T

2792715

G

A

2797814

C

T

2799953

C

T

2800033

C

T

2802765

C

T

2803789

C

T

2804694

C

T

2806670

C

T

2814611

G

A

2815199

C

C/T

2816239

G

A

2821693

G

A

2838356

C

T

2841171

T

T/A

2841177

C

C/G

2841183

C

C/G

2841213

T

T/C

2841228

C

C/G

2841237

G

G/C

2841251

G

G/T

2841255

C

C/A

2841258

G

G/T

2841276

C

C/G

2841293

C

C/G

2841297

C

C/A

2841303

C

C/T

2841306

G

G/A

2841312

T

C/T

2841315

C

G/C

2841322

A

A/T

2841323

G

G/T

2841327

C

G/C

2841335

G

C/G

2841357

G

C/G

2841360

G

C/G

2841369

G

C/G

2841376

T

T/C

2841377

G

T/G

2841384

G

C/G

2841389

T

T/C

2841397

G

G/T

2841398

A

C/A

2841402

G

A/G

2841403

G

C/G

2841409

T

A/T

2841413

G

T/G

2841423

C

G/C

2841444

G

C/G

2841451

C

T/C

2841477

C

G/C

2841514

G

T/G

2841531

A

G/A

2841534

G

C/G

2841536

T

A/T

2841540

C

G/G

2841546

G

C/G

2841552

G

C

2841554

T

C/T

2841555

C

T/C

2841562

C

T/C

2841563

A

C/A

2841569

A

C/A/T

2841575

C

T/C

2841585

C

C/G

2841588

G

C/G

2841594

G

A/G

2841605

C

C/A

2841609

C

C/G

2841617

T

G/T

2841636

G

C/G

2841656

A

C/A

2841660

G

C/G

2841668

C

T/C

2841690

G

C/G

2841700

G

T

2841701

C

T

2841708

G

A/G

2841734

T

C

2841735

C

T

2841738

G

C

2841744

C

G/C

2841747

G

A

2841756

C

G

2841759

G

C

2841762

C

G

2841776

G

T

2841778

T

G

2841783

G

C

2841786

A

T

2841789

C

T

2845157

G

A

2850318

G

A

2851372

G

A

2853353

C

T

2853817

G

A

2868405

C

T

2874011

C

T

2875055

G

A

2875488

G

A

2876911

G

T

2882407

C

T

2888545

C

T

2890510

C

T

2892791

G

A

2896239

G

A

2896828

G

A

2896833

G

A

2899845

C

T

2899865

C

T

2901123

C

T

2905469

C

T

2912026

G

A

2921100

C

T

2934976

G

A

2935134

G

A

2935223

G

A

2945715

G

A

2953167

C

T

2956464

C

T

2965167

G

A

2971031

C

T

2971761

C

T

2973653

C

T

2976296

C

T

2978371

C

T

2983351

G

A

2986416

C

T

2987675

C

T

2988967

C

T

2992035

C

T

2993614

A

G

2994097

G

A

3000921

G

A

3002748

G

A

3003382

G

A

3005352

G

A

3006201

C

T

3021497

G

A

3026718

C

T

3027132

G

A

3031683

C

T

3032969

C

T

3044082

G

A

3045579

G

A

3049857

G

A

3066905

C

T

3079916

T

A/T

3079923

C

C/T

3079936

G

A/G

3079950

A

T/A

3080004

C

C/T

3080006

A

T/A

3080035

C

C/T

3080043

A

C/A

3080063

G

C/G

3080084

C

C/T

3080087

G

C/T/G

3080098

C

C/A

3080128

C

T/C

3080136

A

G/A

3080160

C

G/C

3080161

T

C/T

3080163

T

C/T

3080183

T

C/T

3080192

G

C/G

3080204

G

C/G

3080237

G

C/G

3080288

G

C/G

3080294

G

T/G

3080316

C

C/T

3080321

T

T/C

3080325

G

T/G

3080326

C

T/C

3080355

A

T/A

3080356

A

A/G

3080357

A

A/G

3080359

A

A/G

3080372

A

A/G

3080375

A

A/C

3080382

G

G/A

3080391

A

A/G

3080393

C

C/T

3080394

G

G/A

3080402

A

A/G

3080406

A

A/G

3080418

A

A/G

3080447

C

C/T

3080465

T

T/C

3080472

C

C/T

3080482

A

A/G

3080485

C

C/T

3080496

T

T/C

3082062

G

A

3084014

G

A

3087970

C

T

3089578

G

A

3090231

G

G/C

3101153

G

A

3120006

C

T

3121040

C

T

3125035

C

T

3125407

C

T

3128098

C

T

3131738

C

T

3133651

C

T

3133766

G

A

3137673

C

T

3138173

G

T

3147694

C

T

3148142

C

T

3148342

C

T

3148452

C

T

3148777

C

T

3148960

C

T

3149335

C

T

3151547

C

T

3152279

C

T

3153365

G

A

3156844

C

T

3175067

G

A

3176311

C

T

3180510

C

T

3181134

C

T

3196810

C

T

3198674

G

A

3203788

G

A

3204764

G

T

3208464

G

T

3213080

C

T

3214059

C

T

3216019

C

T

3216133

C

T

3218109

C

T

3226281

C

T

3229241

G

A

3230387

G

A

3235932

C

T

3237109

C

T

3238700

C

T

3241279

C

T

3241643

G

A

3245145

C

T

3247705

G

A

3248186

G

A

3249319

C

T

3251559

G

A

3253347

C

T

3253453

C

T

3253884

G

A

3254464

G

A

3258028

G

A

3258094

G

A

3258637

C

T

3259667

C

T

3261792

G

A

3262978

C

T

3266668

G

A

3266806

C

T

3267341

G

A

3267927

C

T

3268140

T

C

3269676

G

A

3270548

G

A

3275254

A

G

3276870

C

T

3277187

C

T

3279932

C

T

3285105

C

T

3289175

C

T

3289533

C

T

3290417

G

A

3290880

C

T

3291408

C

T

3294618

C

T

3295292

C

T

3296150

C

T

3296689

C

T

3297254

C

T

3297593

G

A

3297802

C

T

3297816

G

A

3299219

C

T

3300457

C

T

3300838

C

T

3300849

C

T

3307410

G

A

3307738

G

A

3309205

C

T

3309441

G

A

3313410

C

T

3314734

C

T

3315483

C

T

3316995

C

T

3318906

C

T

3319964

C

T

3321895

G

A

3326784

G

A

3327191

G

A

3328753

C

T

3336319

C

T

3337206

G

A

3338688

C

T

3345311

C

T

3346757

G

A

3347355

C

T

3347540

C

T

3347560

C

T

3348860

C

T

3349015

C

T

3349651

C

T

3350820

C

T

3351613

C

T

3353030

C

T

3354271

C

T

3354637

C

T

3358411

G

G/A

3358883

G

A

3361525

G

A

3363657

C

T

3368167

C

T

3368381

C

C/T

3375301

C

T

3381507

C

T

3383846

C

T

3386322

C

T

3386914

G

A

3388650

C

T

3388663

C

T

3388840

G

A

3390202

G

A

3391187

C

T

3394129

C

T

3395838

C

T

3396692

C

T

3397717

C

T

3400152

C

T

3402866

G

A

3403044

C

T

3403253

C

T

3404959

C

T

3405078

C

T

3409620

G

A

3412544

G

A

3415574

A

G

3418558

C

T

3418906

G

A

3420004

C

T

3420345

C

T

3429994

C

T

3430020

G

A

3431269

C

T

3432683

G

A

3433788

G

A

3434662

C

T

3435439

G

A

3435661

G

A

3440357

G

A

3441404

C

T

3453288

C

T

3454769

G

A

3456480

C

T

3457161

C

T

3461043

C

T

3461116

G

A

3464902

C

T

3469479

C

T

3473066

G

A

3474749

C

T

3484337

G

A

3484696

C

T

3490633

G

A

3511395

C

T

3517523

G

A

3518338

C

T

3519210

C

T

3519280

C

T

3526212

G

A

3526229

G

A

3532172

C

T

3532281

C

T

3539856

C

T

3540438

C

T

3540952

C

T

3553678

G

A

3558780

G

A

3559503

G

A

3560298

T

C

3572036

C

T

3587529

C

T

3590513

C

T

3590937

C

T

3596971

C

T

3601304

C

T

3610733

G

A

3613460

C

T

3617806

G

A

3618063

C

T

3618082

G

A

3621113

G

A

3625554

C

T

3626449

C

T

3626548

C

T

3627377

C

T

3627686

C

T

3628977

C

T

3632788

C

T

3647003

C

T

3650159

G

A

3658514

C

T

3659174

C

T

3672218

G

A

3695232

G

A

3702963

C

T

3704185

C

T

3704278

G

G/C

3704281

T

T/G

3704282

C

C/T

3704293

T

T/G

3704327

G

A/G

3704335

C

T/C

3704338

C

G/C

3704340

A

C/A

3704371

G

C/G

3704386

T

C/T

3704389

C

G/C

3704395

G

C/G

3704404

G

C/G

3704415

C

T/C

3704427

G

A/G

3704428

C

T/C

3704464

C

T/C

3704484

A

C/A

3704485

C

G/C

3704491

G

C/G

3704512

G

C/G

3704519

A

G/A

3704531

A

GA

3704534

G

C/G

3704536

C

G/C

3704543

C

G/C

3704544

T

C/T

3704554

T

T/G

3704563

C

G/C

3704573

A

GA

3704574

A

G/A

3704577

G

C/G

3704584

C

G/C

3704587

G

A/G

3704590

G

C/G

3704605

T

C/T

3704608

C

G/C

3704617

T

G/T

3704619

A

C/A

3704620

C

A/C

3704629

C

G/C

3704638

C

G/C

3704641

G

C/G

3704647

C

G/C

3704650

G

C/A

3704660

C

A/C

3704662

G

A/G

3704668

T

C/T

3704669

G

A/G

3704670

T

C/T

3704680

C

G/C

3704684

C

G/C

3704686

G

C/G

3704746

G

C/G

3704755

C

C/G

3704767

A

A/G

3704782

T

T/C

3704789

A

VG

3704791

C

C/G

3704806

C

C/T

3704815

T

T/C

3704822

C

C/G

3704844

C

C/A

3704851

A

A/G

3704852

C

C/A

3704866

T

T/C

3704869

C

C/G

3704875

C

C/G

3704906

G

A

3706589

C

C/G

3706625

G

G/C

3706641

G

G/T

3706652

G

G/A

3706655

C

C/G

3706679

T

T/C

3706715

C

C/G

3706735

C

C/G

3706737

A

A/G

3706739

G

G/C

3706784

C

C/T

3706790

T

T/C

3706794

A

A/G

3706805

G

G/C

3706822

A

A/G

3706862

C

C/G

3706926

G

G/T

3706932

A

A/C

3706940

G

G/A

3706945

G

G/C

3706950

T

T/A

3706951

C

C/G

3706958

T

T/C

3706960

A

A/G

3706967

C

C/G

3706983

C

C/G

3706985

G

G/C

3706994

G

G/C

3706996

A

A/C

3707006

G

G/C

3707012

C

C/A

3707013

A

A/G

3707036

C

C/G

3711369

G

A

3713575

C

T

3724878

G

A

3724955

G

A

3727102

G

A

3727130

G

A

3727909

C

T

3732046

C

T

3733052

G

A

3740023

G

A

3741710

G

A

3744813

G

A

3750360

G

A

3756113

C

T

3762328

G

A

3763755

G

A

3764788

G

A

3771690

C

T

3775098

G

A

3775718

G

A

3776484

G

A

3783703

T

C

3786947

G

A

3788243

C

T

3798429

G

A

3799202

G

A

3799222

G

A

3802171

C

T

3806580

C

T

3825163

C

T

3828141

G

A

3831054

G

A

3831114

G

A

3831589

C

T

3831701

G

A

3837175

G

A

3841387

G

A

3843222

C

T

3843509

G

A

3843815

G

A

3844238

G

A

3846121

G

A

3846452

G

A

3852914

T

C

3873931

G

A

3879758

G

A

3883035

C

T

3905636

C

T

3919216

C

T

3920191

G

A

3928659

C

T

3935704

C

C/T

3941486

G

A

3964297

G

A

3965972

G

A

3968608

C

T

3983198

C

T

3993744

G

G/A

4002370

G

A

4004770

C

T

4006580

C

T

4006932

G

A

4013932

G

A

4014337

T

C

4017638

C

T

4019106

G

A

4020770

C

T

4025302

C

T

4027304

G

A

4034139

G

G/T

4043320

A

G

4063459

G

A

4072648

C

T

4073198

C

T

4073446

G

A

4074524

C

T

4081747

C

T

4086210

A

G

4089001

C

T

4102977

C

T

4104004

C

T

4114649

G

A

4117981

G

A

4118234

C

T

4121337

G

A

4124406

G

A

4130087

C

T

4148633

C

T

4150599

C

T

4152842

C

T

4156366

G

A

4156524

G

A

4157742

Ci

A

4157795

Ci

A

4158022

G

A

4160265

G

A

4170648

C

T

4186914

C

T

4187188

G

A

4192330

C

T

4192395

C

T

4194086

C

T

4196729

C

T

4205330

C

T

4218066

G

A

4220842

G

A

4231722

C

T

4251577

C

T

4253562

G

A

4255089

G

A

4268915

C

T

4284264

C

T

4285070

G

A

4286615

G

A

4299670

C

T

4302785

G

A

4302812

C

T

4312528

G

A

4312875

C

T

4314885

G

A

4314896

C

T

4314899

G

A

4316350

C

T

4318874

C

T

4319625

C

T

4324089

G

A

4325174

G

A

4325955

G

A

4327176

C

T

4328372

C

T

4329685

C

T

4329867

C

T

4331851

C

T

4331916

C

T

4334253

C

T

4335755

C

T

4340706

C

T

4343282

T

C

4347901

C

T

4352755

G

A

4360959

G

A

4361293

C

T

4362371

C

T

4365880

G

A

4376161

C

T

4376238

C

T

4378853

G

A

4395837

G

A

4396016

C

T

4402736

C

T

4406151

G

A

4414580

G

A

4414632

C

T

4420655

C

T

4433146

G

A

4438071

G

A

4440571

T

C

4440772

G

A

4443633

G

A

4444731

C

T

4446487

T

C

4463567

C

T

4463766

G

A

4467838

G

A

4474494

G

A

4481185

G

A

4486135

C

T

4487769

G

A

4490385

G

A

4496083

G

A

4499876

C

T

4503563

C

T

4504062

C

T

4517204

G

A

4524639

G

A

4524706

G

A

4529241

G

A

4529778

G

A

4531772

G

A

4532547

G

A

4532943

G

A

4533824

G

A

4535251

G

A

4537480

G

A

4537859

G

A

4543587

G

A

4547764

C

T

4558815

C

T

4558914

C

T

4564648

G

A

4564991

G

A

4573497

C

T

4573536

C

T

4575408

C

T

4577334

C

T

4580403

G

A

4582642

T

C

4588387

C

A

4588663

G

A

4597434

C

T

4598262

C

T

4601247

G

G/C

4601248

T

T/C

4603166

C

T

4611131

C

T

4614475

C

T

4616665

G

A

4617801

G

A

4619989

C

T

4621439

G

A

4626601

G

A

4630752

C

T

4649811

A

A/G

4650590

C

T

4669551

C

T

4670815

G

A

4674426

G

A

4677968

C

T

4688341

C

T

4697092

C

T

4700003

G

A

4702254

C

T

4704691

C

T

4704704

C

T

4713174

C

T

4727776

G

A

4736024

C

T

4766839

C

T

4769655

C

T

4776927

G

A

4788381

C

T

4794373

C

T

4799012

G

A

4812357

C

T

4813704

G

G/T

4813710

G

G/T

4813711

A

A/C

4814060

C

C/T

4814078

C

C/T

4814081

C

C/T

4814082

G

G/C

4814087

T

T/C

4818340

G

A

4820651

C

T

4821863

G

A

4852073

T

T/C

4852080

T

C/T

4852093

T

C/T

4852131

G

A/G

4852238

T

C/T

4857271

T

T/C

4852348

G

G/A

4852373

T

T/C

4858842

C

T

4859921

G

A

4860949

G

A

4872907

G

A

4879205

C

T

4886810

C

T

4889101

G

A

4891956

C

T

4896797

C

T

4903124

G

A

4904325

A

A/G

4904344

C

C/G

4904345

C

C/T

4904355

A

G

4904359

G

G/C

4904360

T

T/C

4908341

C

T

4908687

C

T

4911304

C

T

4916472

C

T

4920831

C

T

4924034

C

T

4924484

C

T

4927068

C

T

4927798

C

T

4929941

C

T

4930693

C

T

4932671

C

T

4933447

T

T/C

4948234

G

A

4950870

C

T

4951932

C

T

4953821

C

T

4978515

G

A

4981742

C

T

4984320

A

G

4987021

G

A

4987606

G

A

4991441

G

A

4992870

G

A

5014441

C

T

5016187

C

T

5016773

C

T

5025119

G

A

5030757

C

T

5053257

C

T

5056010

C

T

5056241

C

T

5058845

C

T

5058850

C

T

5060436

C

T

5061245

C

T

5062621

C

T

5063656

C

T

5063753

A

A/G

5063759

T

T/G

5063766

C

C/T

5063772

A

A/G

5063775

T

T/C

5063777

A

A/G

5063883

T

T/C

5063900

G

G/A

5063967

T

C/T

5063994

C

C/G

5063997

T

C/T

5064000

G

C/G

5064054

C

C/G

5064140

T

A/T

5064188

G

G/C

5064199

G

A/G

5064223

T

C/T

5064318

G

G/A

5064363

G

G/A

5064364

C

C/G

5064368

T

C/T

5066806

C

T

5079654

C

T

5080712

C

T

5080760

G

A

5083716

C

T

5085149

C

T

5087053

C

T

5089288

G

A

5095356

C

T

5096131

C

T

5099106

C

T

5099331

C

T

5099501

C

T

5104316

C

T

5104896

C

T

5105840

C

T

5107273

C

T

5107438

G

A

5110964

G

A

5111341

G

A

5111525

G

A

5113971

C

T

5114926

C

T/C

5114933

C

T/C

5116995

G

A

5117622

G

A

5126463

G

A

5128522

G

A

5131328

G

A

5132598

C

T

5133033

C

T

5134996

G

A

5136119

C

T

5139533

C

T

5141709

G

A

5147647

C

T

5158997

C

T

5171223

G

A

5189948

C

T

5196838

C

T

5203530

G

A

5204859

C

T

5213315

G

A

5216015

G

A

5221083

C

T

5229965

G

A

5233924

G

A

5246591

G

A

5247914

C

T

5253451

C

T

5255901

C

T

5259871

G

A

5270798

G

A

5277822

G

A

5280936

C

T

5283902

G

A

5292603

C

T

5309793

G

A

5317263

G

A

5323245

G

A

5323289

C

T

5323708

G

A

5326705

G

A

5339380

G

A

5349635

C

T

5350111

G

A

5356868

C

T

5363828

C

T

5385564

C

T

5391456

G

A

5404805

G

A

5415953

G

A

5416207

C

T

5419045

C

T

5438747

G

A

5457995

G

A

5465469

C

T

5481386

G

A

5485106

C

T

5500846

G

A

5514802

C

T

5516464

C

T

5530664

C

T

5537010

G

A

5540526

G

A

5541233

C

T

5543634

C

T

5545010

C

T

5545574

G

A

5548499

C

T

5557711

G

A

5574966

C

T

5576016

C

T

5579654

C

T

5582215

C

C/T

5590781

T

T/A

5590796

C

C/T

5590809

T

T/C

5590810

G

G/A

5590823

G

G/A

5590828

A

A/G

5590847

G

G/T

5590861

G

G/C

5590867

A

A/C

5590868

A

A/G

5590886

G

A/G

5590889

T

C/T

5590903

A

G/A

5590909

G

T/G

5590910

C

G/C

5590912

G

T/G

5590918

G

A/G

5590923

A

G/A

5590927

T

G/T

5590933

G

A/G

5590945

C

G/C

5590960

T

C/T

5590961

C

T/C

5590972

T

C/T

5590978

T

C/T

5590981

G

C/G

5590987

T

C/T

5590993

C

G/C

5591002

G

G/A

5591008

T

C/T

5591026

C

G/C

5591035

C

G/C

5591054

C

A/C

5591063

T

C/T

5591065

C

G/C

5591069

A

A/G

5591074

A

G/A

5591077

C

A/C

5591092

A

G/A

5591095

G

C/G

5591098

T

C/T

5591115

G

A/G

5591158

G

T/G

5591179

G

T/G

5591220

C

G/C

5591226

A

G/A

5591268

T

C/T

5591361

C

G/C

5591442

G

A/G

5591445

C

T/C

5591457

G

C/G

5591458

A

C/A

5591466

G

C/G

5591469

G

A/G

5591472

C

G/C

5591476

A

A/G

5591496

G

C/G

5591499

A

C/A

5591505

G

C/G

5591508

T

G/T

5591520

A

G/A

5591532

C

T/C

5591541

C

T/C

5591553

G

A/G

5591562

G

T/G

5591565

G

C/G

5591571

A

G/A

5591577

A

C/A

5591596

C

T/C

5591598

G

C/G

5591607

C

T/C

5591613

T

C/T

5591632

C

A/C

5591635

G

G/T

5591640

T

T/C

5591643

C

C/T

5591654

A

A/C

5591656

A

A/G

5604643

G

A

5612009

C

T

5626626

C

T

5629121

C

T

5631426

C

T

5636810

G

A

5657449

C

T

5659036

G

A

5692125

C

T

5694507

C

T

5696833

C

T

5698190

C

T

5705110

C

T

5708625

C

T

5709728

C

T

5724677

C

T

5727195

C

T

5728510

C

T

5732980

C

T

5738712

G

A

5738846

C

T

5745077

C

T

5751489

C

T

5751716

C

T

5753910

C

T

5755351

C

T

5756752

C

T

5756803

C

T

5760058

C

G

5760301

C

T

5763377

C

T

5764363

C

T

5765100

C

T

5765446

C

T

5767623

C

T

5779664

C

T

5780052

C

T

5781808

C

T

5783477

G

A

5788208

C

T

5790337

C

T

5791404

C

T

5793414

G

A

5795059

C

T

5795465

G

A

5799803

G

A

5803395

C

T

5803716

G

A

5805398

G

A

5805735

G

A

5807160

C

T

5809295

G

A

5810587

G

T

5811908

C

T

5813504

C

T

5813556

C

T

5834083

C

T

5842153

G

C

5843698

T

T/C

5843724

C

C/A

5843727

C

C/T

5843751

G

G/A

5843752

G

G/C

5843766

A

A/G

5843783

A

A/G

5843786

G

G/C

5843787

C

C/G

5843795

G

G/C

5843796

T

T/A

5843797

G

G/T

5843804

C

C/G

5843810

C

C/T

5843818

T

T/C

5843819

T

T/G

5843831

C

C/T

5843863

G

G/T

5843878

C

C/T

5843881

G

G/T

5843888

G

G/A

5843890

G

G/C

5843897

C

C/G

5843899

G

G/T

5843902

C

C/T

5843942

C

C/T

5843965

G

C/G

5843980

C

C/G

5843981

C

C/T

5843987

C

C/G

5843988

C

C/T

5843992

C

C/T

5857131

C

T

5858663

C

T

5879695

G

A

5880188

T

T/C

5880203

G

G/C

5880223

C

C/T

5880241

A

A/C

5880306

C

C/T

5880307

T

T/C

5880349

A

A/T

5880412

G

G/A

5880421

C

C/T

5880430

A

A/G

5880517

T

T/C

5882826

G

A

5887657

G

C/G

5887660

G

C/G

5887684

T

C/T

5887693

T

C/T

5887696

G

C/G

5887718

G

G/A

5887732

G

G/C

5887734

G

G/A

5887765

A

A/G/C

5887771

G

G/C

5887774

G

G/A

5887775

C

C/T

5887784

T

T/C

5887792

T

T/C

5887810

G

G/C

5887813

G

G/C

5887816

G

G/C

5887820

G

G/C

5887824

C

C/G

5887831

G

G/C

5887837

C

C/T

5887843

C

C/G

5887892

G

A/G

5887931

G

G/A/C

5887937

G

G/C

5887938

C

C/G

5887942

C

C/G

5887945

G

G/C

5887951

G

C/G

5887960

G

G/C

5887969

G

G/C

5887970

C

C/G

5887971

A

A/G

5887974

G

G/T

5887975

C

C/T

5887977

T

T/A

5887982

C

C/A/T

5887988

G

G/T

5887990

C

C/G

5888003

A

A/C

5888004

A

A/G

5888005

A

A/G

5888026

C

C/T

5888050

G

G/C

5888053

G

G/C

5888056

G

G/C

5888083

G

G/C

5888092

C

C/G

5888095

C

C/G

5888102

G

G/A

5888103

T

T/C

5888122

C

C/T

5888143

G

G/C

5890782

G

G/C

5890839

T

C/T

5890849

T

A/T

5890851

C

G/C

5890863

C

G/C

5890864

G

A/G

5890869

G

T/G

5890872

C

T/C

5890893

C

T/C

5890899

C

T/C

5890906

G

A/G

5890908

G

G/A

5890914

C

T/C

5890920

C

G/C

5890923

C

T/C

5890926

C

G/C

5890971

C

C/T

5890992

C

C/T

5891058

G

C/G

5891061

G

C/G

5891070

C

T/C

5891094

T

C/T

5891097

C

C/G

5891100

C

C/T

5891121

C

T/C

5891142

G

G/C

5891145

C

C/G

5891148

G

C/G

5891187

G

G/C

5891220

G

G/C

5891247

T

T/C

5891250

C

C/T

5891263

T

T/C

5892300

C

C/T

5892304

A

A/C

5892312

C

C/G

5892330

C

C/T

5892370

A

A/G

5892413

C

C/T

5892414

T

T/C

5892456

A

A/T

5892519

G

G/A

5894264

G

A

5894322

G

A

5894986

A

A/G

5894989

T

T/C

5895041

G

G/A

5895043

C

C/G

5895049

C

C/G

5895054

T

T/C

5895058

G

G/C

5895073

C

C/G

5895100

G

G/C

5895106

C

G/C

5895108

T

C/T

5895115

C

G/C

5895118

A

C/A

5895127

C

G/C

5895130

C

G/C

5895137

A

T/A

5895142

T

C/T

5895147

G

C/G

5895181

C

T/C

5895254

A

G/A

5895280

T

C/T

5895283

G

C/G

5895298

C

G/C

5895299

G

A/G

5895319

C

G/C

5895328

C

T/C

5895334

C

T/C

5895340

G

C/G

5895346

G

G/C

5895349

C

T/C

5895358

C

T/C

5895361

C

G/C

5895370

C

C/T

5895391

C

T/C

5895436

G

C/G

5895437

A

G/A

5895439

C

G/C

5895493

G

C/G

5895496

G

C/G

5895505

C

T/C

5895529

T

C/T

5895532

C

G/C

5895577

G

C/G

5895580

C

G/C

5895628

T

C/T/G

5895629

T

CT

5895661

C

C/G

5895847

C

C/G

5895878

G

G/A

5895898

C

C/T

5895899

A

A/C

5895915

A

G/A

5895949

C

T/C

5896081

C

G/C

5896085

C

T/C

5896090

C

T/C

5896115

C

C/T

5896120

A

A/G

5896123

G

G/C

5896126

T

T/C

5896147

T

T/G

5896148

T

T/C

5896154

T

T/C

5896156

G

G/C

5896159

G

G/C

5896246

T

T/C

5896279

C

T/C

5896312

A

A/G

5896324

A

A/G

5896333

G

G/A

5896381

G

G/C

5900925

C

C/G

5900943

G

G/T

5900949

C

C/A

5900955

C

C/T

5900958

C

C/G

5900965

T

T/C

5900971

G

G/C

5900972

C

C/G

5900997

C

C/T

5901000

C

C/T

5901015

A

A/C

5901034

C

C/A

5901048

C

C/T

5901050

G

GA

5901057

C

C/T

5901068

G

G/A

5901071

A

A/G

5901078

G

G/T

5901099

C

C/T

5901123

T

T/A

5901135

G

C/G

5901172

G

A/G

5901186

G

G/A

5901195

T

T/C

5901204

G

G/A

5901219

C

A/C

5901342

T

C/T

5901345

T

T/G

5901346

T

T/C

5901354

C

C/G

5901615

C

T/C

5901617

G

C/G

5901660

C

C/G

5901664

T

T/G

5901669

C

A/C

5901673

T

A/T

5901675

C

G/C

5901679

C

C/T

5901688

C

T/C

5901689

T

A/T

5901690

G

C/G

5901698

C

A/C

5901712

G

A/G

5901713

T

A/T

5901714

T

T/C

5901719

G

G/C

5901726

G

G/C

5901729

C

C/G

5901732

C

C/T

5901733

G

G/A

5901738

C

C/G

5901752

C

C/T

5901757

G

G/A

5901764

T

C/T

5901767

C

G/C

5901771

G

C/G

5901790

C

G/C

5901791

G

C/G

5901793

G

A/G

5901807

G

C/G

5901824

G

A/G

5901826

G

GA

5901830

T

T/G

5901840

A

A/C

5902914

C

T

5905708

G

A

5925008

C

T

5925517

G

A

5926357

G

A

5928875

C

T

5930205

C

T

5933164

G

A

5947433

C

T

5957471

G

A

5960825

C

T

5961809

T

G/T

5961866

T

T/A

5970914

C

T

5975910

A

G/A

5975911

A

G/A

5975926

A

G/A

5978267

C

T

6005749

C

T

6009383

G

A

6010024

C

T

6026234

C

T

6033950

C

T

6042035

C

T

6050103

C

C/T

6050112

A

C/A

6050115

G

G/C

6050116

C

C/G

6050118

G

G/A

6050509

G

A/G

6050536

G

G/C

6050556

G

C/G

6050557

C

A/C

6050584

T

T/A

6050694

T

T/C

6050727

A

G/A

6050730

G

C/G

6050769

G

G/A

6050820

A

A/C

6050822

T

T/C

6050824

C

C/T

6050947

T

C/T

6050949

A

G/A

6050952

T

T/C

6050958

G

A/G

6050965

A

C/A

6050971

T

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8983102

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9008254

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T

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A

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T

9045846

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A

9049564

C

T

9052240

C

T

9052265

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A

9053107

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9058239

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A

9060181

C

T

9064090

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T

9072129

C

C/T.

2. A microorganism comprising the DNA of claim 1 , wherein said microorganism is Actinoplanes utahensis.

3. A method for producing Acarbose comprising the steps:

a) cultivating the microorganism of claim 2 to produce Acarbose; and

b) harvesting said Acarbose produced by the microorganism.

Assignments (2)
CHANGE OF ADDRESS Recorded Jun 12, 2023
From: BAYER INTELLECTUAL PROPERTY GMBH
To: BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 064021/0344 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 24, 2014
From: SELBER, KLAUS, DR.; WEINGAERTNER, BERNHARD, DR.; WEHLMANN, HERMANN, DR.; ROSEN, WINFRIED, DR.; SCHWIENTEK, PATRICK; KALINOWSKI, JORN, DR.; WEHMEIER, UDO, DR.; PUHLER, ALFRED, DR.
To: BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 032280/0089 →