Muscle-based grafts/implants
View Patent ↗The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
1. An implant comprising a porous matrix formed from fibers of defatted, shredded, allogeneic human tissue;
wherein the porous matrix is formed into a shape and dried; and
wherein said implant has the property of holding its shape during rehydration and handling.
2. The implant of claim 1 , wherein the allogneic human tissue is tendon, fascia, ligament or dermis.
3. The implant of claim 1 , wherein said shape is selected from the group consisting of a strip, a sheet, a molded 3D shaped object, a sponge, and a gasket.
4. The implant of claim 3 , wherein said shape also includes a cavity, a pouch, a hole, a post, a hook, or a suture.
5. The implant of claim 3 , wherein said shape is a strip having dimensions of about 10 mm to 500 mm long, by 10 mm to 200 mm wide and 1 mm to 10 mm thick.
6. The implant of claim 5 , wherein said shape is a strip having dimensions of about 50 mm to 90 mm long by 15 mm to 35 mm wide and 2 mm to 5 mm thick.
7. The implant of claim 3 , wherein said shape is a strip having a cross section of a rectangle, square, triangle, other polygon, circle, half circle, ellipse, or partial ellipse.
8. The implant of claim 3 , wherein said shape is a disk having dimensions of about 10 mm to 100 mm diameter and 1 mm to 10 mm thick.
9. The implant of claim 3 , wherein said shape is a molded 3D shape having dimensions of about 100 mm by 100 mm and 25 mm thick.
10. The implant of claim 9 , wherein said shape is a molded 3D shape having dimensions of about 50 mm by 70 mm and 20 mm thick.
11. The implant of claim 10 , wherein said shape is a molded 3D shape having dimensions of about 30 mm by 50 mm and 15 mm thick.
12. The implant of claim 3 wherein said shape is a molded 3D shape designed to fit into a particular anatomical feature or surgically created space.
13. The implant of claim 1 , wherein the implant further comprises particles of demineralized bone matrix (DBM), mineralized bone matrix, cortical cancellous chips CCC, crushed cancellous chips, tricalcium phosphate, hydroxyapatite, or biphasic calcium phosphate dispersed in the matrix.
14. The implant of claim 13 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
15. The implant of claim 14 , wherein the implant comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
16. The implant of claim 14 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
17. The implant of claim 1 , which has been treated to remove or neutralize antigenic proteins, bacteria and viruses.
18. The implant of claim 1 , which has a moisture content of 3% or less.