Radically polymerizable phenothiazine macromonomer for use in the coating of medical devices
View Patent ↗The present invention is directed to phenothiazine-based macromonomer compounds and methods of making the same.
1. A compound having the Formula:
wherein
R 1 , R 2 , and R 3 are independently selected from the group consisting of H, OH, F, Cl, Br, I, O—R, and a substituted or unsubstituted lower alkyl group having between 1 and 4 carbon atoms, where said alkyl group may be substituted with one or more hydroxyl or halide groups;
R is H or a lower alkyl group having between 1 and 4 carbon atoms;
W is H or a moiety derived from the group having the formula
and
Linker is derived from polyethylene glycol or a substituted or unsubstituted aliphatic group having between about 2 and about 12 carbon atoms.
2. The compound of claim 1 , wherein said compound has the Formula (X)
3. The compound of claim 1 , wherein said compound has the Formula (Xa)
where n is an integer ranging from 1 to 12.
4. The compound of claim 1 , wherein said Linker is derived from polyethylene glycol.
5. The compound of claim 1 , wherein R 1 , R 2 , and R 3 are independently selected from H, methyl, ethyl, propyl, or butyl.
6. The compound of claim 1 , wherein at least one of R 1 , R 2 , and R 3 is H.
7. A compound having the following formula:
8. The compound of claim 7 , wherein said Linker is derived from polyethylene glycol.
9. The compound of claim 7 , wherein said compound has the Formula (IXa)
wherein n is an integer ranging from 1 to 12.
10. A polymer comprising at least one unit comprising the compound of claim 1 .
11. A polymer comprising at least two units comprising the compound of claim 1 .
12. The polymer of claim 10 , wherein said polymer is crosslinked to a biological molecule.
13. The polymer of claim 10 , wherein said polymer is crosslinked to a different polymer or copolymer.
14. A viscous solution comprising the polymer of claim 10 and a biological molecule.
15. The viscous solution of claim 14 , wherein said biological molecule is an enzyme.
16. The viscous solution of claim 14 , wherein said biological molecule is flavin adenine dinucleotide.
17. The viscous solution of claim 14 , wherein said biological molecule is nicotinamide adenine dinucleotide.
18. The viscous solution of claim 14 , wherein said biological molecule is trapped within a matrix of said polymer.
19. A film coating comprising the polymer of claim 10 .
20. A medical device comprising a coating comprising the polymer of claim 10 , wherein said coating is at least partially applied to at least one surface of said medical device.
21. The medical device of claim 20 , wherein said medical device is a sensor, a transducer, or an electrode.
22. A method of polymerizing or crosslinking said compounds of claim 1 , wherein said method comprises reacting at least two equivalents of the compounds of claim 1 in the presence of a catalyst to form a polymer, said catalyst selected from the group consisting of an initiator, heat, or UV-radiation.
23. The method of claim 22 , wherein said crosslinking is performed in the presence of one or more biological molecules.
24. The method of claim 22 , wherein said method further comprises the step of reacting said polymer with terminal reactive functional groups.
25. The method of claim 22 , wherein said polymerization is performed on the surface of a medical device.
26. The method of claim 25 , wherein said medical device is a sensor, a transducer, or an electrode.