Lipidated immune response modifier compound compositions, formulations, and methods
View Patent ↗The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be used, for example, as a vaccine adjuvant and a cancer treatment.
1. A compound of formula:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound of claim 1 .
3. A pharmaceutical composition comprising the compound of claim 1 in a formulation comprising liposomes.
4. The pharmaceutical composition of claim 2 , further comprising an antigen.
5. The pharmaceutical composition of claim 4 , wherein the compound and antigen are admixed into a single composition.
6. The pharmaceutical composition of claim 4 , wherein the compound and antigen are present in separate components of the composition to be administered in combination.
7. The pharmaceutical composition of claim 4 wherein the antigen is a cancer vaccine.
8. The pharmaceutical composition of claim 4 wherein the antigen is a viral vaccine.
9. A method of enhancing the effectiveness of a vaccine antigen by administering as a vaccine adjuvant the compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof.
10. The method of claim 9 , wherein the compound is incorporated into a liposome formulation.
11. The pharmaceutical composition of claim 3 , further comprising an antigen.
12. The pharmaceutical composition of claim 4 , wherein the antigen is an influenza vaccine.
13. The pharmaceutical composition of claim 4 , wherein the antigen is at least one hemagglutinin antigen.
14. The method of claim 9 , wherein the vaccine antigen is at least one influenza antigen.
15. The method of claim 9 , wherein the vaccine antigen is at least one hemagglutinin antigen.