Peptide having the ability to regenerate bone tissue and for binding to apatite
View Patent ↗The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.
1. An isolated peptide having bone tissue regeneration capacity and binding to apatite, in which one peptide of amino acid sequence SEQ ID NO: 35 and one peptide of amino acid sequence SEQ ID NO: 36 are linked to each other.
2. A bone graft material in which the peptide of claim 1 is immobilized on a surface of apatite.
3. The bone graft material of claim 2 , wherein the apatite is selected from the group consisting of organism-derived hydroxyapatite bone minerals, synthetic hydroxyapatite, carbonated apatite, tricalcium phosphate, and monocalcium phosphate.
4. The bone graft material of claim 2 , wherein the peptide is contained in a content of 1˜100 mg per unit weight (1 g) of the bone graft material.
5. A biomaterial for bone regeneration, in which the peptide of claim 1 is immobilized on a surface of apatite.
6. The biomaterial for bone regeneration of claim 5 , wherein the biomaterial is selected from the group consisting of metals, natural polymers, and synthetic polymers.
7. The biomaterial for bone regeneration of claim 5 , wherein the apatite is selected from the group consisting of organism-derived hydroxyapatite bone minerals, synthetic hydroxyapatite, carbonated apatite, tricalcium phosphate, and monocalcium phosphate.
8. The biomaterial for bone regeneration of claim 5 , wherein the peptide is contained in a content of 1˜100 mg per unit weight (1 g) of the biomaterial for bone regeneration.
9. A method for bone tissue regeneration, the method comprising the step of grafting the peptide according to claim 1 into a recipient site.
10. A method for bone tissue regeneration, the method comprising the step of grafting a composition containing the peptide according to claim 1 into a recipient site.
11. The method for bone tissue regeneration of claim 10 , wherein the composition is a bone graft material or a biomaterial for bone regeneration.
12. An isolated peptide having bone tissue regeneration capacity and binding to apatite, wherein the peptide is represented by the amino acid sequence of SEQ ID NO: 40.
13. A bone graft material in which the peptide of claim 12 is immobilized on a surface of apatite.
14. The bone graft material of claim 13 , wherein the apatite is selected from the group consisting of organism-derived hydroxyapatite bone minerals, synthetic hydroxyapatite, carbonated apatite, tricalcium phosphate, and monocalcium phosphate.
15. The bone graft material of claim 13 , wherein the peptide is contained in a content of 1˜100 mg per unit weight (1 g) of the bone graft material.
16. A biomaterial for bone regeneration, in which the peptide of claim 12 is immobilized on a surface of apatite.
17. The biomaterial for bone regeneration of claim 16 , wherein the biomaterial is selected from the group consisting of metals, natural polymers, and synthetic polymers.
18. The biomaterial for bone regeneration of claim 16 , wherein the apatite is selected from the group consisting of organism-derived hydroxyapatite bone minerals, synthetic hydroxyapatite, carbonated apatite, tricalcium phosphate, and monocalcium phosphate.
19. The biomaterial for bone regeneration of claim 16 , wherein the peptide is contained in a content of 1˜100 mg per unit weight (1 g) of the biomaterial for bone regeneration.
20. A method for bone tissue regeneration, the method comprising the step of grafting the peptide according to claim 15 into a recipient site.
21. A method for bone tissue regeneration, the method comprising the step of grafting a composition containing the peptide according to claim 12 into a recipient site.
22. The method for bone tissue regeneration of claim 21 , wherein the composition is a bone graft material or a biomaterial for bone regeneration.