Synergistic ophthalmic compositions for disinfecting contact lenses
View Patent ↗Compositions and methods for disinfecting contact lenses using the compositions are disclosed. The compositions include a combination of alexidine and chlorhexidine, which surprisingly causes the composition to exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.
1. An ophthalmic composition comprising:
from 0.8 ppm to 1.05 ppm alexidine;
from 2 ppm to 5 ppm chlorhexidine; and
from about 0.5 ppm to about 3.3 ppm poly[(dimethyliminio)-2-butene-1,4-diyl chloride], α-[4-[tris(2-hydroxyethyl)ammonio]-2-butenyl]-Ω-[tris(2-hydroxyethyl)ammonio]-dichloride,
wherein the composition exhibits synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 2.4 log.
2. The ophthalmic composition of claim 1 , further comprising a chelating agent.
3. The ophthalmic composition of claim 2 , wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA).
4. The ophthalmic composition of claim 1 , wherein EDTA is present at a concentration of from about 0.05% to about 1% by weight per volume.
5. The ophthalmic composition of claim 1 , further comprising a surfactant.
6. The ophthalmic composition of claim 1 , further comprising a buffer agent.
7. The ophthalmic composition of claim 6 , wherein the buffer agent is a boric acid and borate buffering system.
8. The ophthalmic composition of claim 1 , further comprising a tonicity component.
9. The ophthalmic composition of claim 8 , wherein the tonicity component is sodium chloride.
10. The ophthalmic composition of claim 1 , further comprising sodium citrate.
11. The ophthalmic composition of claim 1 , further comprising a viscosity-inducing component.
12. The ophthalmic composition of claim 1 , further comprising from about 0.05% to about 0.25% by weight per volume hydroxypropyl methylcellulose.
13. The ophthalmic composition of claim 1 , further comprising from about 0.039% to about 0.15% by weight per volume hydroxypropyl methylcellulose.
14. An ophthalmic composition comprising:
from 0.8 ppm to 1.05 ppm alexidine;
from 2 ppm to 5 ppm chlorhexidine;
from about 0.5 ppm to about 3.3 ppm poly[(dimethyliminio)-2-butene-1,4-diyl chloride], α-[4-[tris(2-hydroxyethyl)ammonio]-2-butenyl]-Ω-[tris(2-hydroxyethyl)ammonio]-dichloride;
from about 0.04 to about 0.15% by weight per volume of ethylenediaminetetraacetic acid (EDTA);
from about 0.18 to about 0.70% by weight per volume of sodium chloride;
from about 0.50 to about 0.66% by weight per volume of boric acid;
from about 0.15 to about 0.30% by weight per volume of sodium borate;
from about 0.22 to about 0.80% by weight per volume of sodium citrate;
from about 0.03 to about 0.15% by weight per volume of a surfactant; and
from about 0.03 to about 0.25% by weight per volume of a viscosity-inducing component,
wherein alexidine and chlorhexidine together exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by 2.4 to 4.0 log.
15. A method of disinfecting a contact lens comprising: contacting the contact lens with a disinfecting solution, the disinfecting solution including the ophthalmic composition of claim 1 ; and removing the contact lens from the disinfecting solution.
16. The method of claim 15 , wherein the contacting step includes contacting the contact lens with the disinfection solution for at least six hours.
17. The method of claim 15 , wherein the disinfection solution further includes from about 0.05% to about 1% weight per volume ethylenediaminetetraacetic acid (EDTA).
18. The ophthalmic composition of claim 1 , comprising 0.8 ppm alexidine.
19. The ophthalmic composition of claim 1 , comprising 1.05 ppm alexidine.