Stable formulations for parenteral injection of small molecule drugs

1. A method for treating or preventing anxiety, muscle spasms, or seizures, the method comprising parenterally administering to a subject in need thereof a stable liquid formulation comprising: (a) a biocompatible solvent consisting of dimethylsulfoxide (DMSO) or a mixture of DMSO and n-methyl pyrrolidone (NMP); and (b) a small molecule drug, or a salt thereof, solubilized within the solvent, wherein the small molecule drug is diazepam, and wherein diazepam is present in the liquid formulation in an amount up to its solubility limit in the formulation, wherein the liquid formulation comprises less than 5% by weight residual water, and wherein a volume of the liquid formulation to be parenterally injected is 3 ml or less.

2. The method of claim 1 , further comprising the injectable volume within a device for dispensing the liquid formulation.

3. The method of claim 2 , wherein the device is a syringe, a pen injection device, an auto-injector device, an external or implantable pump, or a perfusion bag.

4. The method of claim 1 , wherein the liquid formulation comprises 50 mg/ml to 300 mg/ml of diazepam.

5. The method of claim 1 , wherein the volume of the liquid formulation to be parenterally injected is from 0.1 μl to 1 μl.

6. The method of claim 1 , wherein the volume of the liquid formulation to be parenterally injected is from 1 μl to 10 μl.

7. The method of claim 1 , wherein the volume of the liquid formulation to be parenterally injected is from 10 μl to 1 ml.

8. The method of claim 1 , wherein the liquid formulation is not diluted prior to administration.