Hydration prevention coating
View Patent ↗Occlusion devices and delivery systems are described in which a polymerizing oil is used to protect a hydrogel from premature swelling. In an embodiment, a delivery system includes an occlusion device releasably coupled within a catheter sheath. The occlusion device includes an expandable implant and a hydrogel. An at least partially oxidized polymerizing oil is inside a lumen of the catheter sheath between the distal end of the catheter sheath and the hydrogel.
1. A delivery system comprising:
a catheter sheath having a distal end, a proximal end, and a lumen therebetween;
an occlusion device releasably coupled within the catheter sheath, the occlusion device comprising an expandable implant and at least one hydrogel sleeve on the expandable implant including a distal hydrogel sleeve having a distal end; and
a polymerizing oil inside a portion of the lumen of the catheter sheath between the distal end of the catheter sheath and the distal end of the distal hydrogel sleeve, wherein the polymerizing oil is at least partially oxidized to form a plug within the catheter sheath, at a location distal to the distal hydrogel sleeve.
2. The delivery system of claim 1 , wherein the polymerizing oil comprises a cross-linked skin.
3. The delivery system of claim 2 , wherein the polymerizing oil protects the at least one hydrogel sleeve from swelling upon exposure of the distal end of the catheter sheath to a physiological environment.
4. The delivery system of claim 3 , wherein the catheter sheath can be withdrawn to expose the at least one hydrogel sleeve.
5. The delivery system of claim 4 , wherein the cross-linked skin can be torn by withdrawal of the catheter sheath to expose the at least one hydrogel sleeve.
6. The delivery system of claim 2 , wherein the polymerizing oil comprises an incompletely cured portion which is encapsulated by the cross-linked skin and the catheter sheath.
7. The delivery system of claim 2 , wherein the polymerizing oil comprises oxidized alpha-linolenic acid.
8. The delivery system of claim 2 , wherein the polymerizing oil is characterized as including at least 20% by weight alpha-linolenic acid as a percentage of fatty acid composition prior to being partially oxidized.
9. The delivery system of claim 8 , wherein the polymerizing oil comprises linseed oil.
10. The delivery system of claim 2 , wherein the polymerizing oil does not encapsulate a proximal end of the at least one hydrogel sleeve.
11. The delivery system of claim 2 , wherein the polymerizing oil comprises a conjugated oil.
12. The delivery system of claim 11 , wherein the conjugated oil is selected from the group consisting of tung oil and oiticica oil.
13. The delivery system of claim 2 , wherein the polymerizing oil has an iodine value above 130.
14. The delivery system of claim 2 , wherein the polymerizing oil partially encapsulates the distal hydrogel sleeve.
15. The delivery system of claim 2 , wherein the catheter sheath extends beyond the distal hydrogel sleeve to form the portion of the lumen between the distal end of the catheter sheath and the distal end of the distal hydrogel sleeve.
16. The delivery system of claim 2 , wherein the polymerizing oil is not substantially formed over the distal hydrogel sleeve.
17. The delivery system of claim 1 , wherein the at least one hydrogel sleeve is a preformed hollow cylinder attached to the expandable implant.
18. The delivery system of claim 17 , wherein the hollow cylinder is attached to the expandable implant with glue.