Compositions containing fluorine substituted olefins and methods and systems using same
View Patent ↗Disclosed are the use of fluorine substituted olefins, including tetra- and penta-fluoropropenes, in a variety of applications, including in methods of depositing catalyst on a solid support, methods of sterilizing articles, cleaning methods and compositions, methods of applying medicaments, fire extinguishing/suppression compositions and methods, flavor formulations, fragrance formulations and inflating agents.
1. A low toxicity method of applying a cosmetic material, a medicament or other therapeutic component to an organism comprising:
(a) providing a composition comprising: (i) the cosmetic, medicament or other therapeutic component and (ii) low toxicity propellant comprising at least about 5% by weight of 1,1,1,3-tetrafluoropropene, wherein said 1,1,1,3-tetrafluorpropene consists of trans-1,1,1,3-tetrafluoropropene (transHFO-1234ze); and
(b) introducing said composition to the organism.
2. The method of claim 1 wherein said organism is a human.
3. The method of claim 1 wherein said introducing step comprises providing said composition to a metered dose inhaler (MDI) and discharging the composition from said MDI.
4. The method of claim 1 wherein said transHFO-1234ze is present in said propellant in an amount of from about 5% by weight to about 99% by weight.
5. The method of claim 1 wherein said transHFO-1234ze is present in said propellant in an amount of from about 5% by weight to about 95% by weight.
6. The method of claim 1 wherein said composition consists essentially of a medicament and/or other therapeutic component and said transHFO-1234ze.
7. The method of claim 1 wherein said propellant consists essentially of transHFO-1234ze.
8. The method of claim 1 wherein said propellant consists of transHFO-1234ze.
9. The method of claim 2 wherein said introducing step comprises providing said composition to a metered dose inhaler (MDI) and discharging the composition from said MDI.
10. The method of claim 6 wherein said introducing step comprises providing said composition to a metered dose inhaler (MDI) and discharging the composition from said MDI.
11. The method of claim 7 wherein said introducing step comprises providing said composition to a metered dose inhaler (MDI) and discharging the composition from said MDI.
12. The method of claim 11 wherein said organism is a human.
13. The method of claim 1 wherein said organism is a human, said composition comprises medicament or other therapeutic component, and said introducing step comprising introducing said composition to the human by inhalation.
14. The method of claim 1 wherein said organism is a human, said composition comprises medicament or other therapeutic component, and said introducing step comprises delivering said composition to the lungs or mucosal membranes of said human.
15. The method of claim 14 wherein said propellant is substantially nonflammable.
16. The method of claim 1 wherein said organism is a human and said composition comprises a cosmetic.
17. The method of claim 16 wherein said cosmetic is selected from deodorants, perfumes, hair sprays, cleansers, and polishing agents.
18. The method of claim 16 wherein said cosmetic is a deodorant.
19. The method of claim 16 wherein said cosmetic is a hair sprays.
20. The method of claim 7 wherein said organism is a human and said composition comprises a cosmetic.
21. The method of claim 20 wherein said cosmetic is selected from deodorants, perfumes, hair sprays, cleansers, and polishing agents.
22. The method of claim 20 wherein said cosmetic is a deodorant.
23. The method of claim 20 wherein said cosmetic is a hair sprays.
24. The method of claim 1 wherein said organism is a human, wherein said propellant is substantially nonflammable, and wherein said composition comprises a cosmetic.
25. The method of claim 24 wherein said cosmetic is selected from deodorants, perfumes, hair sprays, cleansers, and polishing agents.
26. The method of claim 24 wherein said cosmetic is a deodorant.
27. The method of claim 24 wherein said cosmetic is a hair spray.
28. A method of applying a cosmetic, medicament or other therapeutic component to an organism comprising:
(a) providing a composition comprising: (i) the cosmetic, medicament or other therapeutic component and (ii) propellant comprising at least about 5% to about 99% by weight of 1,1,1,3-tetrafluoropropene, wherein said 1,1,1,3-tetrafluorpropene consists of trans-1,1,1,3-tetrafluoropropene (transHFO-1234ze),
provided that said propellant does not contain fluroalkene having an unsaturated terminal carbon with no H substituents; and
(b) introducing said composition to the organism.
29. The method of claim 28 wherein said propellant has an acute toxicity as measured by inhalation exposure to mice and rats that is substantially lower than the acute toxicity of HFO-1225zc.
30. The method of claim 29 wherein said organism is a human.
31. The method of claim 29 wherein said organism is a human, said composition comprises medicament or other therapeutic component, and said introducing step comprises introducing said composition to the human by inhalation.
32. The method of claim 31 wherein said organism is a human, said composition comprises medicament or other therapeutic component, and said introducing step comprises delivering said composition to the lungs or mucosal membranes of said human.
33. The method of claim 32 wherein said propellant is substantially nonflammable.
34. The method of claim 28 wherein said organism is a human and said composition comprises a cosmetic.
35. The method of claim 34 wherein said cosmetic is selected from deodorants, perfumes, hair sprays, cleansers, and polishing agents.
36. The method of claim 34 wherein said cosmetic is a deodorant.
37. The method of claim 34 wherein said cosmetic is a hair spray.
38. The method of claim 30 wherein said composition comprises a cosmetic.
39. The method of claim 38 wherein said cosmetic is selected from deodorants, perfumes, hair sprays, cleansers, and polishing agents.
40. The method of claim 38 wherein said cosmetic is a deodorant.
41. The method of claim 38 wherein said cosmetic is a hair spray.
42. The method of claim 28 wherein said composition comprises a cosmetic and wherein said propellant is substantially nonflammable.
43. The method of claim 42 wherein said cosmetic is selected from deodorants, perfumes, hair sprays, cleansers, and polishing agents.
44. The method of claim 42 wherein said cosmetic is a deodorant.
45. The method of claim 42 wherein said cosmetic is a hair spray.