Methods and systems for minimizing and treating cardiac fibrillation

1. A method for using feedback to at least one of minimize and treat cardiac fibrillation in a patient, comprising:

obtaining one or more measurements of tissue activation frequency across a cardiac tissue substrate in the patient's heart using a data collection unit;

obtaining with a processing unit a map of one or more measurements indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across the cardiac tissue substrate based on the one or more measurements of tissue activation frequency, said map being registered onto a representation of the patient's heart;

defining an optimal placement of at least one ablation lesion in the cardiac tissue substrate;

applying ablation lesion therapy based on the optimal placement of the at least one ablation lesion;

determining whether the ablation lesion therapy at least one of minimized and treated cardiac fibrillation; and

if the ablation lesion therapy is determined to have not at least one of minimized and treated cardiac fibrillation, repeating the steps of generating, defining, applying, and determining until ablation lesion therapy at least one of minimizes and treats cardiac fibrillation.

2. A system using feedback to at least one of minimize and treat cardiac fibrillation in a patient, comprising:

a processing unit configured to process a map of one or more measurements of tissue activation frequency across a cardiac tissue substrate in the patient's heart indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across a cardiac tissue substrate, said measurements of tissue activation frequency taken with at least a data collection unit, said map being registered onto a representation of the patient's heart, to define an optimal placement of at least one ablation lesion in the cardiac tissue substrate, to apply ablation lesion therapy based on the optimal placement of the at least one ablation lesion, to determine whether the ablation lesion therapy at least one of minimized and treated cardiac fibrillation, and

if the ablation lesion therapy is determined to have not at least one of minimized and treated cardiac fibrillation, to repeat the steps of generating, defining, applying, and determining until ablation lesion therapy at least one of minimizes and treats cardiac fibrillation; and

a storage unit to store data and executable instructions to be used by the processing unit.

3. The method of claim 1 , wherein the step of determining whether the ablation lesion therapy at least one of minimized and treated cardiac fibrillation comprises:

assessing fibrillogenicity of the cardiac tissue substrate to determine whether the fibrillogenicity is below a predetermined threshold.

4. The method of claim 3 , wherein assessing the fibrillogenicity of the cardiac tissue substrate comprises at least one of:

calculating a total length of the at least one ablation lesion, wherein the total length is indicative of the fibrillogenicity;

obtaining one or more measurements indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across a cardiac tissue substrate; and

obtaining one or more measurements including at least one measure of surface area of the cardiac tissue substrate, total boundary length of the cardiac tissue substrate, and wavelength of fibrillatory waves.

5. The method of claim 4 , wherein the one or more measurements indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across a cardiac tissue substrate include at least one measure indicative of tissue activation wavelength and minimum area of the cardiac tissue substrate required to support one electrical circuit.

6. The method of claim 4 , wherein the at least one measure of surface area of the cardiac tissue substrate and total boundary length of the cardiac tissue substrate is obtained from at least one of a cardiac magnetic resonance imaging scan, computed tomography scan, rotational angiogram, three-dimensional ultrasound model, and three-dimensional electro-anatomic map.

7. The method of claim 4 , wherein the at least one measure of wavelength of fibrillatory waves is obtained from an electrocardiogram.

8. The method of claim 1 , wherein the one or more measurements include at least one measure of electrogram signal frequency.

9. The method of claim 1 , wherein the optimal placement is based on one or more optimization criteria indicative of a level of optimization to which a sample set of lesions can at least one of minimize and terminate cardiac fibrillation and comprising at least one of a predetermined length threshold and a predetermined density threshold.

10. The method of claim 9 , wherein defining the optimal placement comprises repeating steps of generating a sample set of lesions, calculating a total length of the sample set of lesions, comparing the total length of the sample set of lesions to the predetermined length threshold, and determining a level of optimization of the sample set of lesions until the one or more optimization criteria are met.

11. The system of claim 2 , wherein the processing unit is configured to determine whether the ablation lesion therapy at least one of minimized and treated cardiac fibrillation by assessing fibrillogenicity of the cardiac tissue substrate to determine whether the fibrillogenicity is below a predetermined threshold.

12. The system of claim 11 , the processing unit is further configured to assess the fibrillogenicity by calculating a total length of the at least one ablation lesion, wherein the total length is indicative of the fibrillogenicity.

13. The system of claim 2 , further comprising a data collection unit to obtain at least one of:

one or more measurements indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across a cardiac tissue substrate; and

one or more measurements including at least one measure of surface area of the cardiac tissue substrate, total boundary length of the cardiac tissue substrate, and wavelength of fibrillatory waves.

14. The system of claim 13 , wherein the data collection unit uses at least one of cardiac magnetic resonance imaging, computed tomography, rotational angiography, three-dimensional ultrasound, and three-dimensional electro-anatomic mapping to obtain the at least one measure of surface area of the cardiac tissue substrate and total boundary length of the cardiac tissue substrate.

15. The system of claim 13 , wherein the data collection unit uses electrocardiography to obtain the at least one measure of wavelength of fibrillatory waves.

16. The system of claim 2 , wherein the one or more measurements include at least one measure of electrogram signal frequency.

17. The system of claim 2 , wherein the optimal placement is based on one or more optimization criteria indicative of a level of optimization to which a sample set of lesions can at least one of minimize and terminate cardiac fibrillation and comprising at least one of a predetermined length threshold and a predetermined density threshold.

18. The system of claim 17 , wherein the processing unit is configured to define the optimal placement by repeating steps of generating a sample set of lesions, calculating a total length of the sample set of lesions, comparing the total length of the sample set of lesions to the predetermined length threshold, and determining a level of optimization of the sample set of lesions until the one or more optimization criteria are met.