IP Library › Granted Patent US 9,156,894
Granted Patent B2
US 9,156,894 · App. 13/845,305 · Granted Oct 13, 2015

Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870

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Quick Facts
Patent No.
US 9,156,894
App. No.
13/845,305
Granted
Oct 13, 2015
Kind
B2
Abstract

NMB1870 is a protein in Neisseria meningitidis . Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.

Claims (2)

1. A hybrid polypeptide comprising an amino acid sequence having at least 85% identity to SEQ ID NO: 36.

2. The hybrid polypeptide of claim 1 , comprising an amino acid sequence having at least 90% identity to SEQ ID NO: 36.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2016
From: NOVARTIS VACCINES AND DIAGNOSTICS SRL
To: GLAXOSMITHKLINE BIOLOGICALS SA
Reel/Frame 040077/0814 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 14, 2016
From: MASIGNANI, VEGA; SCARSELLI, MARIA; RAPPUOLI, RINO; PIZZA, MARIAGRAZIA; GIULIANI, MARZIA MONICA
To: NOVARTIS VACCINES AND DIAGNOSTICS SRL
Reel/Frame 039162/0523 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 14, 2016
From: NOVARTIS VACCINES AND DIAGNOSTICS SRL
To: NOVARTIS AG
Reel/Frame 039162/0530 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 14, 2016
From: NOVARTIS AG
To: GLAXOSMITHKLINE BIOLOGICALS SA
Reel/Frame 039348/0942 →