Manufacturing and packaging room temperature stable dronabinol capsules
View Patent ↗The invention provides a method of manufacturing and packaging a room temperature stable cannabinoid dosage in an oil-based carrier, wherein the method employs the use of blister packaging and an inert gas atmosphere during blister packaging. The invention also provides a room temperature stable cannabinoid dosage prepared by the methods of the invention.
1. A method of manufacturing and packaging a cannabinoid dosage, consisting of the following steps:
a) preparing a fill solution with a desired concentration of a cannabinoid in a liquid carrier;
b) encapsulating said fill solution in capsules;
c) packaging said capsules in a closed packaging system; and
d) removing atmospheric air from the capsules,
wherein the removing of atmospheric air consists solely of purging said packaging system with an inert gas, and wherein said packaging system provides a room temperature stable product.
2. The method of claim 1 , wherein the packaging system is a blister package.
3. The method of claim 2 wherein the blister package is constructed of material that minimizes exposure to moisture and air.
4. The method of claim 1 , wherein the cannabinoid is dronabinol.
5. The method of claim 1 , wherein the liquid carrier is oil-based carrier.
6. The method of claim 5 , wherein the oil-based carrier is sesame oil.
7. The method of claim 1 , wherein the capsules are soft gelatin capsules.
8. The method of claim 1 , wherein the inert gas is nitrogen.
9. The method of claim 1 , wherein the desired cannabinoid concentration is about 1-10% w/w.
10. The method of claim 9 wherein the desired concentration is about 1.5-6.5% w/w.