IP Library › Patent Application 13855596
Patent Application
App. No. 13/855,596

GLUE COMPOSITION FOR LUNG VOLUME REDUCTION

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Quick Facts
Patent No.
US None
App. No.
13/855,596
Abstract

The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

Claims (5)

1 . A composition for sealing lung tissue, comprising:

a bifunctional chemical linker;

a first adhering moiety connected via a first amide bond linkage to a first site on the bifunctional chemical linker; and

a second adhering moiety connected via a second amide bond linkage to a second site on the bifunctional chemical linker,

wherein the first and second adhering moieties adhere to different sites bearing elastase in a lung, and each adhering moiety comprises a member selected from the group consisting of an alpha-1 antitrypsin, an elafin, and a serpin.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 5, 2014
From: GONG, GLEN; DIECK, RONALD
To: PNEUMRX, INC.
Reel/Frame 032359/0591 →