LIQUID PREPARATION FOR ORAL ADMINISTRATION USED FOR CT COLONOGRAPHY AND COMPOSITION FOR GASTROINTESTINAL RADIOGRAPHY
The present invention provides a liquid preparation for oral administration that is capable of reducing the amount of colonic irrigation solution taken during gastrointestinal pretreatment and decreasing the burden on the subject without sacrificing test accuracy and without prolonging the time required for pretreatment, and a composition for gastrointestinal radiography used to prepare the liquid preparation for oral administration. Namely, provided are a liquid preparation for oral administration taken during gastrointestinal imaging by CT colonography that comprises an iodine compound and a water-soluble polymer or saline laxative, wherein 300 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations, and a composition for gastrointestinal radiography comprising an iodine compound and a water-soluble polymer or saline laxative, wherein 300 mL to 1200 mL are taken in the form of an aqueous solution, having an iodine content of 3.5 mg/mL to 90 mg/mL prepared by dissolving in water, on the day before CT colonography in a single administration or divided among several administrations.
1 . A liquid preparation for oral administration taken during gastrointestinal imaging by CT colonography, comprising:
an iodine compound and a water-soluble polymer or saline laxative, wherein
300 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations.
2 . The liquid preparation for oral administration according to claim 1 , wherein 600 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations.
3 . The liquid preparation for oral administration according to claim 1 , wherein the iodine compound is nonionic.
4 . The liquid preparation for oral administration according to claim 1 , wherein the water-soluble polymer is one or more selected from the group consisting of polyethylene glycol, polydextrose, dextran, dextrin, hydroxyethyl starch, gum arabic, pullulan, pectin, albumin and carboxymethyl cellulose.
5 . The liquid preparation for oral administration according to claim 1 , wherein osmotic pressure is 200 mOsm/L to 440 mOsm/L.
6 . The liquid preparation for oral administration according to claim 1 , further comprising one or more of sugars selected from the group consisting of sucrose, sorbitol, xylitol, erythritol, mannitol, trehalose, lactitol, lactulose, maltitol, palatinose, raffinose and glycerin.
7 . The liquid preparation for oral administration according to claim 1 , wherein the content of the iodine compound is 3.5 mg/mL to 90 mg/mL.
8 . The liquid preparation for oral administration according to claim 1 , further comprising one or more of compounds selected from the group consisting of dimethylpolysiloxane and gastrointestinal function accelerators.
9 . A composition for gastrointestinal radiography, comprising:
an iodine compound and a water-soluble polymer or saline laxative, wherein
300 mL to 1200 mL are taken in the form of an aqueous solution, having an iodine content of 3.5 mg/mL to 90 mg/mL prepared by dissolving in water, on the day before CT colonography in a single administration or divided among several administrations.
10 . The composition for gastrointestinal radiography according to claim 9 , wherein 600 mL to 1200 mL are taken in the form of an aqueous solution, having an iodine content of 3.5 mg/mL to 90 mg/mL prepared by dissolving in water, on the day before CT colonography in a single administration or divided among several administrations.
11 . The composition for gastrointestinal radiography according to claim 9 , wherein the iodine compound is nonionic.
12 . The composition for gastrointestinal radiography according to claim 9 , comprising:
electrolytes such that the osmotic pressure when dissolved in water is 200 mOsm/L to 440 mOsm/L, and
one or more of water-soluble polymers selected from the group consisting of polyethylene glycol, polydextrose, dextran, dextrin, hydroxyethyl starch, gum arabic, pullulan, pectin, albumin and carboxymethyl cellulose, or
one or more of saline laxatives selected from the group consisting of magnesium citrate, sodium dihydrogen phosphate and disodium hydrogen phosphate.
13 . The composition for gastrointestinal radiography according to claim 9 , further comprising one or more of compounds selected from the group consisting of dimethylpolysiloxane and gastrointestinal function accelerators.
14 . A pharmaceutical agent for pretreatment for CT colonography, comprising:
combining an iodine compound and a water-soluble polymer or saline laxative, wherein
300 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations.
15 . The pharmaceutical agent for pretreatment for CT colonography according to claim 14 , wherein 600 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations.
16 . A pharmaceutical agent for pretreatment for CT colonography, comprising:
combining an oral colonic irrigation agent and an iodine-containing contrast agent, wherein
300 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations.
17 . The pharmaceutical agent for pretreatment for CT colonography according to claim 16 , wherein 600 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations.