Devices and methods for treating defects in the tissue of a living being
View Patent ↗An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.
1. A flowable bone implant for the repair or regeneration of bone tissue in a living being, said bone implant comprising a tissue conductive matrix, at least a portion of said tissue conductive matrix comprising a blend of soluble collagen, at least one ceramic, and native insoluble collagen fibers, wherein at least a portion of said implant is porous, and further wherein said porous implant has a pore size that is at least about 100 microns, wherein at least at a time of implantation said implant has a consistency of a substance selected from the group consisting of a putty and a paste, and further wherein said flowable implant comprises an implant that is capable of being delivered through a delivery system, and further wherein said implant is arranged to be implanted in the body of the living being, and still further wherein said delivery system comprises a syringe, tubular housing, or cannula,
wherein said flowable bone implant is capable of conforming to the shape of the defect being treated.
2. The implant of claim 1 , wherein said collagen comprises biological constituents.
3. The implant of claim 2 , wherein said biological constituents comprises at least one of angiogenic agents, anti-inflammatory agents, arteriogenesis agents, chondroitin, cytokines, prostaglandins, glycosaminoglycans, growth factors, heparin, hyaluronic acid, integrins, peptides, polypeptides, proteins, proteoglycans, or combinations thereof.
4. The implant of claim 1 , wherein said matrix further comprises a therapy comprising at least one drug or biologically active agent.
5. The implant of claim 1 , wherein said matrix further comprises at least one polymer other than collagen.
6. The implant of claim 5 , wherein said polymer is synthetic.
7. The implant of claim 5 , wherein said polymer is at least partially bio-resorbable.
8. The implant of claim 7 , wherein said polymer comprises chitin, PGA/PLLA copolymers, hydrogel, Lactide/.mu.-caprolactone copolymers, PGA, PLA, or PCL.
9. The implant of claim 5 , wherein said polymer is osteoinductive.
10. The implant of claim 1 , wherein said collagen comprises cellular materials.
11. The implant of claim 10 , wherein said cellular materials comprise at least one of glycoproteins, growth factors, and sources of growth factors.
12. The implant of claim 1 , wherein the native collagen fibers further comprise at least one of elastin, hyaluronic acid, polysaccharides, salts.
13. The implant of claim 1 , wherein said ceramic comprises calcium phosphate, calcium sulfate, or hydroxyapatite.
14. The implant of claim 1 , wherein said at least one ceramic is in the form of particles, and further wherein said ceramic is blended with said tissue conductive matrix.
15. The implant of claim 1 , wherein said tissue conductive matrix further comprises reconstituted collagen.
16. The implant of claim 1 , wherein said tissue conductive matrix is bio-matched.
17. The implant of claim 16 , wherein said bio-matched, tissue conductive matrix comprise a tissue conductive matrix that is at least one of integrity matched, porosity matched, compliance matched or weight matched.
18. The implant of claim 1 , wherein said tissue conductive matrix exhibits elastic recovery after being compressed.
19. The implant of claim 1 , wherein said pores make up more than 50 percent by volume of said porous portion.
20. The implant of claim 1 , wherein said implant is located in said living being at a site of a bone defect.
21. The implant of claim 1 wherein said implant having a consistency of putty or paste further comprises thrombin glue, or growth factor gelatin.
22. A flowable bone implant for the repair or regeneration of bone tissue of a living being, said bone implant comprising a tissue conductive matrix, at least a portion of said tissue conductive matrix comprising a blend of soluble collagen, at least one ceramic, and native insoluble collagen fibers, wherein at least a portion of said implant is porous, and further wherein said porous implant has a pore size that is at least about 100 microns, and further wherein said implant being in a form selected from the group consisting of sponges and loose, fibrous materials, and further wherein said flowable implant comprises an implant that is capable of being delivered through a delivery system, and further wherein said implant is arranged to be implanted in the body of said living being, and still further wherein said delivery system comprises a syringe, tubular housing, or cannula,
wherein said flowable bone implant is capable of conforming to the shape of the defect being treated.
23. The implant of claim 22 , wherein said collagen comprises biological constituents.