Prolyl hydroxylase inhibitors and method of use
View Patent ↗The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.
1. A compound having the formula:
wherein R 2 is chosen from:
i) —OR 6 ; or
ii) —NR 7a R 7b ;
R 6 is hydrogen, methyl or ethyl;
R 7a and R 7b are independently hydrogen, methyl or ethyl; or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein R 2 is —OR 6 .
3. The compound according to claim 2 , wherein R 6 is hydrogen.
4. The compound according to claim 2 , wherein R 6 is methyl.
5. The compound according to claim 1 , wherein R 2 is —NR 7a R 7b .
6. The compound according to claim 5 , wherein R 7a and R 7b are each independently hydrogen or methyl.
7. The compound according to claim 6 , wherein R 2 is —NH 2 .
8. The compound {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid.
9. A composition, comprising:
A) a compound having the formula:
wherein R 2 is chosen from:
i) —OR 6 ; or
ii) —NR 7a R 7b ;
R 6 is hydrogen, methyl or ethyl;
R 7a and R 7b are independently hydrogen, methyl or ethyl; or a pharmaceutically acceptable salt thereof; and
B) one or more pharmaceutically acceptable ingredients.
10. The composition according to claim 9 , wherein R 2 is —OR 6 .
11. The composition according to claim 10 , wherein R 6 is hydrogen.
12. The composition according to claim 10 , wherein R 6 is methyl.
13. The composition according to claim 9 , wherein R 2 is —NR 7a R 7b .
14. The composition according to claim 13 , wherein R 7a and R 7b are each independently hydrogen or methyl.
15. The composition according to claim 14 , wherein R 2 is —NH 2 .
16. The composition according to claim 9 , wherein the compound is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, or a pharmaceutically acceptable salt thereof.
17. A compound having the formula:
or a pharmaceutically acceptable salt thereof.