IP Library Granted Patent US 9,180,319
Granted Patent B2
US 9,180,319 · App. 13/864,226 · Granted Nov 10, 2015

Laser assisted periodontium and osseus regeneration protocol

Inventor: Margaret V. Kalmeta (Aptos, CA)
A61Q11/00A61C1/0046A61C19/063A61K8/20A61K8/24A61K8/368A61K8/416A61K8/44A61K8/442A61K8/606A61N5/0603A61N5/0613A61N5/062A61N2005/067A61N2005/0659
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Quick Facts
Patent No.
US 9,180,319
App. No.
13/864,226
Granted
Nov 10, 2015
Kind
B2
Abstract

A method of treating gum disease using a soft tissue diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400 nm-700 nm) at a laser power of 0.5 to 1.2 watts, used with intermittent stops to control tissue temperature, to decontaminate the gum tissue and biostimulate the periodontium nonsurgically when used with a substrate, thus preventing the long junctional epithelium from migrating into the sulcus, preserving tissue height, and regenerating periodontium, the method comprising: placing the tip of the laser inside the sulcus; penetrating the entire sulcus by moving the laser light with intermittent stops to control tissue temperature vertically and horizontally throughout the sulcus; and placing a substrate in the sulcus prior to a blood clot forming, thus regenerating periodontium in the sulcus.

Claims (31)

1. A substrate mixture for the treatment of gum disease, wherein the substrate mixture is comprised of:

a) a first substrate; and

b) a second substrate,

wherein the first substrate is comprised of:

a) between 40% and 80% sterile water

b) 1.1% sodium chloride;

c) 1% benzoic acid;

d) 9% lysine;

e) 9% proline;

f) 9% essential amino acids, wherein the essential amino acids include equal parts isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, valine and histadine;

g) 2% non-essential amino acids, wherein the non-essential amino acids include equal parts alanine, arginine, glutamate, glycine and serine;

h) 2% phosphates, wherein the phosphates include equal parts adenosine diphospate (ADP), adenosine triphosphate (ATP), and acetylcholine; and

i) 6.9% free bases, wherein the free bases include equal parts adenosine, uridine, guanosine, and cytidine.

2. The substrate mixture of claim 1 , wherein the second substrate is comprised of:

a) tricalcium phosphate; and

b) hydroxyapatite crystals.

3. The substrate mixture of claim 1 , wherein the first substrate includes aspartate in an equal amount relative to the other non-essential amino acids.

4. The substrate mixture of claim 1 , wherein the first substrate includes aspartate in a greater amount relative to the other non-essential amino acids.

5. The substrate mixture of claim 1 , wherein the substrate mixture has a pH of about 7.4.

6. The substrate mixture of claim 2 , wherein the tricalcium phosphate is precipitated in calcium hydroxide and devil's claw oil.

7. The substrate mixture of claim 2 , wherein the hydroxyapatite crystals are precipitated in calcium hydroxide and devil's claw oil.

8. The substrate mixture of claim 2 , wherein the tricalcium phosphate is in the form of crystals.

9. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are 10-50 micro meter in size.

10. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are 50-150 micro meter in size.

11. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are 100-300 micro meter in size.

12. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are 500-1000 micro meter in size.

13. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are 1-3 mm in size.

14. The substrate mixture of claim 2 , wherein the hydroxyapatite crystals are non-porous.

15. The substrate mixture of claim 2 , wherein the hydroxyapatite crystals are porous.

16. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are non-porous.

17. The substrate mixture of claim 8 , wherein the tricalcium phosphate crystals are porous.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPLICATION NO. 17/545179 TO THE CORRECT APPLICATION NO. 17545178 PREVIOUSLY RECORDED AT REEL: 060751 FRAME: 0708. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 17, 2022
From: BIOREGENTECH INC.
To: THE BIOREGENTECH INSTITUTE, INC.
Reel/Frame 061476/0663 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2022
From: BIOREGENTECH INC.
To: THE BIOREGENTECH INSTITUTE, INC.
Reel/Frame 060751/0708 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2021
From: KALMETA, MARGARET V.
To: BIOREGENTECH, INC.
Reel/Frame 055377/0781 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 24, 2020
From: KALMETA, MARGARET V.
To: BIOREGENTECH, INC.
Reel/Frame 051696/0212 →
Continuity (2)
Continuation In Part 13078757 · Apr 1, 2011
Related Publication 20140141389A1 · May 22, 2014