Abuse potential reduction in abusable substance dosage form
View Patent ↗The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.
1. A method for reducing potential for substance abuse from a skin-worn transdermal patch device comprising an abusable substance layer containing residual amounts of an abusable substance of interest after removal from a user, the method comprising:
inserting the transdermal patch device into a container and thereby contacting the abusable substance layer of the transdermal patch device as removed from a user to an anti-abuse substance present in an anti-abuse layer that is attached to an interior wall of the container, wherein the anti-abuse substance is selected from the group consisting of co-soluble antagonists, irritants and combinations thereof so that the potential for abuse is reduced.
2. A method as in claim 1 wherein said anti-abuse substance includes an amount of an antagonist.
3. A method as in claim 1 wherein said anti-abuse substance includes an amount of an irritant.
4. A method as in claim 1 wherein said abusable substance is an opioid.
5. A method as in claim 4 wherein said opioid is fentanyl.
6. A system for reducing potential for substance abuse from a skin-worn transdermal patch device comprising an abusable substance layer containing residual amounts of abusable substance after administration to a user, said system comprising:
(a) a disposable container having an opening therein to receive a skin-worn patch device containing a residual amount of an abusable substance therein;
(b) an anti-abuse layer attached to an interior wall of the container and containing an amount of an anti-abuse substance selected from the group consisting of co-soluble antagonists, irritants and combinations thereof, said anti-abuse layer being disposed in said container in a manner such that a skin-worn patch device properly inserted into said container causes said abusable substance of said skin-worn patch device to contact said anti-abuse substance; and
(c) a closure for closing said container containing a used skin-worn patch device.
7. A system as in claim 6 wherein said anti-abuse substance includes an amount of an irritant.
8. A system as in claim 6 wherein said anti-abuse substance includes an amount of an antagonist.
9. A system as in claim 6 wherein said container is a flexible pouch.
10. A system as in claim 6 wherein said closure includes an adhesive seal.
11. A method for reducing potential for substance abuse from a skin-worn transdermal patch device having an abusable substance layer containing a residual amount of an abusable substance of interest and an anti-abuse layer, the method comprising:
contacting said abusable substance layer with said anti-abuse layer by removing the transdermal patch from a user and thereby removing a membrane from between the abusable substance layer and the anti-abuse layer, wherein said anti-abuse layer comprises a substance selected from the group consisting of co-soluble antagonists, irritants and combinations thereof.
12. A method as in claim 11 wherein said abusable substance is an opioid.
13. A method as in claim 11 wherein said opioid is fentanyl.
14. A method as in claim 11 wherein said anti-abuse substance comprises an amount of an irritant.
15. A method as in claim 11 wherein said anti-abuse substance comprises an amount of a co-soluble antagonist.
16. A method as in claim 11 wherein said membrane comprises an aspect which adhesively attaches to the user when said patch is applied to the user, and wherein removing the membrane from between the abusable substance layer and the anti-abuse layer comprises moving the abusable substance layer and the anti-abuse layer away from the user while retaining the aspect against the user.