Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising an effective amount of the compound of claim 1 in a pharmaceutically acceptable carrier.
3. A compound of the formula:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising an effective amount of the compound of claim 3 in a pharmaceutically acceptable carrier.
5. A compound of the structure:
wherein R 2 is -(alkylene) m -heterocyclo or -(alkylene) m -heteroaryl,
R is hydrogen, and
X is independently CH or N.
6. The compound of claim 5 , wherein R 2 is -(alkylene) m -heterocyclo.
7. The compound of claim 5 , wherein m is 0.
8. The compound of claim 6 , wherein m is 0.
9. The compound of claim 5 , wherein m is 1.
10. The compound of claim 6 , wherein m is 1.
11. The compound of claim 5 , wherein the heterocyclo is not substituted.
12. The compound of claim 6 , wherein the heterocyclo is not substituted.
13. The compound of claim 5 , wherein R 2 is
14. A pharmaceutical composition comprising an effective amount of the compound of claim 5 in a pharmaceutically acceptable carrier.
15. A compound of the structure:
wherein R 2 is -(alkylene) m -heterocyclo or -(alkylene) m -heteroaryl,
R is hydrogen, and
X is independently CH or N.
16. The compound of claim 15 , wherein R 2 is -(alkylene) m -heterocyclo.
17. The compound of claim 15 , wherein m is 0.
18. The compound of claim 16 , wherein m is 0.
19. The compound of claim 15 , wherein m is 1.
20. The compound of claim 16 , wherein m is 1.
21. The compound of claim 15 , wherein the heterocyclo is not substituted.
22. The compound of claim 16 , wherein the heterocyclo is not substituted.
23. The compound of claim 15 , wherein R 2 is
24. A pharmaceutical composition comprising an effective amount of the compound of claim 15 in a pharmaceutically acceptable carrier.