PREPARATIONS AND METHODS FOR AMELIORATING OR REDUCING PRESBYOPIA
This application relates to the use of one or more parasympathomimetic drugs in combination with one or more alpha agonists to create optically beneficial miosis to, for example, temporarily treat presbyopia. The invention provides a pharmaceutical preparation comprising a therapeutically effective amount of one or more parasympathomimetic drugs or cholinesterase inhibitors, or a pharmaceutically acceptable salt thereof, in combination with one or more alpha agonists or antagonists, or a pharmaceutically acceptable salt thereof. The invention further provides for a method for treating, ameliorating or reducing presbyopia of a patient having an eye, comprising administering to said eye a pharmaceutically effective amount of the ophthalmic preparation.
1 . A method for ameliorating or reducing presbyopia of a patient having an eye, comprising administering to said eye an ophthalmic preparation comprising a therapeutically effective amount of carbachol, or pharmaceutically acceptable salts thereof, and brimonidine, or pharmaceutically acceptable salts thereof.
2 . The method of claim 1 , wherein carbachol is present in the preparation in an amount of 1.5-5%.
3 . The method of claim 1 , wherein carbachol is present in the preparation in an amount of 2.25-3.5%.
4 . The method of claim 1 , wherein brimonidine is present in the preparation in an amount of 0.05-0.3%.
5 . A method of producing ocular miosis in a subject which comprises administering to the subject an amount of an ophthalmic preparation comprising a therapeutically effective amount of carbachol, or pharmaceutically acceptable salts thereof, and brimonidine, or pharmaceutically acceptable salts thereof, effective to produce ocular miosis.
6 . The method of claim 5 , wherein carbachol is present in the preparation in an amount of 1.5-5%.
7 . The method of claim 5 , wherein carbachol is present in the preparation in an amount of 2.25-3.5%.
8 . The method of claim 5 , wherein brimonidine is present in the preparation in an amount of 0.05-0.3%.
9 . A method for ameliorating or reducing presbyopia of a patient, comprising administering to one eye of the patient a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of carbachol, or pharmaceutically acceptable salts thereof, and brimonidine, or pharmaceutically acceptable salts thereof.
10 . The method of claim 9 , wherein carbachol is present in the preparation in an amount of 1.5-5%.
11 . The method of claim 9 , wherein carbachol is present in the preparation in an amount of 2.25-3.5%.
12 . The method of claim 9 , wherein brimonidine is present in the preparation in an amount of 0.05-0.3%.
13 . A method of ameliorating, reducing or eliminating dimness of vision of a patient having an eye comprising administering to said eye a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of carbachol, or pharmaceutically acceptable salts thereof, and brimonidine, or pharmaceutically acceptable salts thereof.
14 . The method of claim 13 , wherein carbachol is present in the preparation in an amount of 1.5-5%.
15 . The method of claim 13 , wherein carbachol is present in the preparation in an amount of 2.25-3.5%.
16 . The method of claim 13 , wherein brimonidine is present in the preparation in an amount of 0.05-0.3%.
17 . A method of improving focus and/or correcting refractive errors of a patient having an eye comprising administering to said eye a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of carbachol, or pharmaceutically acceptable salts thereof, and brimonidine, or pharmaceutically acceptable salts thereof.
18 . The method of claim 17 , wherein carbachol is present in the preparation in an amount of 1.5-5%.
19 . The method of claim 17 , wherein carbachol is present in the preparation in an amount of 2.25-3.5%.
20 . The method of claim 17 , wherein brimonidine is present in the preparation in an amount of 0.05-0.3%.
21 . A method of treating presbyopia in a patient in need of treatment thereof comprising administering an effective amount of an ophthalmic preparation comprising a therapeutically effective amount of carbachol, or pharmaceutically acceptable salts thereof, and brimonidine to a single eye of a patient thereby leaving the other eye untreated.
22 . The method of claim 21 , wherein carbachol is present in the preparation in an amount of 1.5-5%.
23 . The method of claim 21 , wherein carbachol is present in the preparation in an amount of 2.25-3.5%.
24 . The method of claim 21 , wherein brimonidine is present in the preparation in an amount of 0.05-0.3%.