TGR5 modulators and methods of use thereof
The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
1. A method of ameliorating a disease in a subject in need thereof, comprising administering compound Ih3e:
or a pharmaceutically acceptable salt or glycine or taurine amino acid conjugate wherein the disease is selected from a metabolic disease, wherein the metabolic disease is selected from metabolic syndrome, insulin resistance, pre-diabetic insulin resistance, hypertension, and dyslipidemia.
2. The method of claim 1 , wherein the disease is metabolic syndrome.
3. The method of claim 1 , wherein the disease is insulin resistance.
4. The method of claim 1 , wherein the compound is a free acid.
5. The method of claim 1 , wherein the compound is a pharmaceutically acceptable salt.
6. The method of claim 1 , wherein the compound is a glycine amino acid conjugate.
7. The method of claim 1 , wherein the compound is a taurine amino acid conjugate.
8. The method of claim 1 , further comprising administering at least one pharmaceutically acceptable excipient.