Risperidone Immunoassay
Novel conjugates and immunogens derived from risperidone and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of risperidone and paliperidone in biological fluids.
1 - 5 . (canceled)
6 . A compound of the formula:
wherein Y, B, X and p are above;
wherein B is
Y is an organic spacing group;
X is a terminal functional group capable of binding to a carrier; and
p is an integer from 0 to 1.
7 . The compound of claim 6 , wherein p is 0.
8 . The compound of claim 7 , wherein X is
wherein R 3 is hydrogen, a halide, a hydroxyl, or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
9 . The compound of claim 8 wherein X is
10 . The compound of claim 8 wherein X is
11 . The compound of claim 8 , wherein X is
and R 3 is hydroxyl.
12 . The compound of claim 8 , wherein X is
and R 3 forms a reactive ester.
13 . The compound of claim 12 , wherein the ester formed is a lower alkyl ester, imidoester or amidoester.
14 . The compound of claim 6 , wherein p is 1.
15 . The compound of claim 14 , wherein X is
wherein R 3 is hydrogen, a halide, a hydroxyl, or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
16 . The compound of claim 15 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
17 . The compound of claim 16 , wherein Y is lower alkylene containing from 1 to 6 carbon atoms.
18 . The compound of claim 17 , wherein X is
and R 3 is as above.
19 . The compound of claim 16 , wherein Y is
wherein m and o are as above.
20 . The compound of claim 19 , wherein X is
and R 3 is as above.
21 . A conjugate comprising a carrier conjugated with a ligand of the formula:
wherein B is
Y is an organic spacing group;
X is a functional linking group capable of linking to a carrier; and
p is an integer from 0 to 1.
22 . The conjugate of claim 21 , wherein the carrier contains a polyamine polymer.
23 . The conjugate of claim 22 , wherein p is 0.
24 . The conjugate of claim 23 , wherein X is
wherein R 3 is hydrogen, a halide, a hydroxyl, or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
25 . The conjugate of claim 22 , wherein p is 1.
26 . The conjugate of claim 25 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
27 . The conjugate of claim 26 , wherein X is
wherein R 3 is hydrogen, a halide, a hydroxyl, or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
28 . The conjugate of claim 22 , wherein said polyamine polymer is an immunogenic polymer.
29 . The conjugate of claim 28 wherein Y is an alkylene containing from 1 to 6 carbon atoms.
30 . The conjugate of claim 25 , wherein X is
and R 3 is as above.
31 . The conjugate of claim 25 , wherein Y is
where m and o are as above.
32 . The conjugate of claim 31 , wherein X is
and R 3 is as above.