Polymeric bone foam composition and method
View Patent ↗Biomaterials, in particular bone foams, a process for preparing such materials as well as an applicator for applying the biomaterials directly to the patient's application site, and the use of a composition comprising water, a surfactant and a propellant in the preparation of a bone foam for the preparation of a calcium phosphate foam wherein the foam is obtainable by the mixture of at least two phases, a first phase comprising water and optionally a propellant, a second phase comprising one or more sources for calcium and/or phosphate, and wherein the foaming is performed during the mixture of the at least two phases to provide an improved calcium phosphate foam, process for the preparation of a calcium phosphate foam, use of a composition, solid state structure, calcium phosphate cement foam and bone foam applicator.
1. A process for preparing a calcium phosphate bone foam comprising:
mixing a) a first phase comprising water, a propellant in the amount of 5% to 25% by weight of the first phase, and a stabilizing agent in the amount of 0.1% to 10% by weight of the first phase, and
b) a second phase comprising a calcium and/or phosphate source, and initiating foaming during the mixing of the first and second phases,
wherein the calcium and/or phosphate source is selected from the group consisting of:
a) a calcium/phosphate compound is selected from the group consisting of: tetracalcium phosphate, dicalcium phosphate anhydride, dicalcium phosphate dihydrate, alpha tricalcium phosphate, beta tricalcium phosphate, monocalcium phosphate monohydrate, hydroxyapatite, calcium deficient hydroxyapatite, fluorapatite, amorphous calcium phosphate, calcium-sodium- and potassium-phosphate, calcium- and sodium-phosphate, calcium- and potassium-phosphate, and calcium pyrophosphate;
b) a composition comprising a calcium compound and a phosphate compound, wherein
i. the calcium compound is selected from the group consisting of calcium carbonate, calcium sulphate, calcium sulphate hemi hydrate, calcium oxide, and calcium hydroxide; and
ii. the phosphate compound selected from the group consisting of: phosphoric acid, primary phosphates, dihydrogen phosphates, secondary phosphates, hydrogen phosphates, tertiary phosphates, alkaline phosphates, alkaline earth phosphates, NaH 2 PO 4 , KH 2 PO 4 , Na 2 HPO 4 , K 2 HPO 45 Na 3 PO 4 , and K 3 PO 4 ; and
c) a mixture of at least the calcium/phosphate compound defined in option a) and at least the composition defined in option b),
wherein the foaming is performed during mixing of the two phases and wherein the calcium phosphate bone foam has a viscosity between 100 and 100,000 cP at 20° C.
2. The process of claim 1 , wherein the stabilizing agent is selected from the group consisting of a surfactant, gelling agent, primary phosphates, dihydrogen phosphates, secondary phosphates, hydrogen phosphates, tertiary phosphates, alkaline phosphates, alkaline earth phosphates, NaH 2 PO 4 , KH 2 PO 4 , Na 2 HPO 4 , K 2 HPO 45 Na 3 PO 4 , K 3 PO 4 , organic acids, and combinations thereof.
3. The process of claim 2 , wherein the surfactant is at least one of
(i) a cationic, anionic or non-ionic surfactant;
(ii) a polymeric surfactant; or
(ii) PEGylated fatty acid derivatives, PEGylated glycerol fatty acid derivatives, PEGylated sorbitan fatty acid, and polypropylene glycol-PEG-blockpolymer derivatives and preferably is selected from the group consisting of PEG-35-glycerol rizinoleate, PEG-40-gycerol-hydro xystearate, polypropylene glycol-PEG-blockpolymer, PEG-15-hydroxystearate, or PEG-20-sorbitan-monooleate.
4. The process of claim 1 , wherein the propellant in the first phase is selected from the group consisting of propane, butane, iso-butane, heptafluoropropane, pentafluorobutane, and tetrafluoroethane and any mixtures thereof.
5. The process of claim 1 , wherein the first phase is formulated with a vapor pressure of the propellant of about 1.1 to about 8 bar.
6. The process of claim 1 , wherein the first phase further comprises at least one component selected from the group consisting of binders, accelerators, cohesion promoters, and any mixtures thereof, wherein the binder is polyvinylpyrrolidone and the accelerator is selected from the group consisting of: Na 2 HPO 4 , NaH 2 PO 4 , tri-sodiumcitrate dihydrate, KH 2 PO 4 , or K 2 HPO 4 and combinations thereof; and
the second phase further comprises a component selected from the group consisting of: an alcohol, a propellant, and combinations thereof.
7. The process according to claim 1 , wherein the particle size of the calcium and/or phosphate source is in the range of 0.05 to 100 μm.
8. The process of claim 1 , wherein the second phase comprises tetra-calcium phosphate, di-calcium phosphate or mixture thereof, wherein the ratio of tetra-calcium phosphate to di-calciumphosphate is between 1:5 and 5:1.
9. The process of claim 1 , wherein the foam further comprises an anticancer agent, an antibiotic, an antioxidant, a viable cell, a growth factor or a combination thereof.
10. The process of claim 1 , wherein the foam sets in less than 60 min at 37° C., and the ratio of the first phase to the second phase is between 10:1 and 1:10.