IP Library › Patent Application 13886788
Patent Application
App. No. 13/886,788

OPHTHALMIC COMPOSITIONS WITH IMPROVED DESSICATION PROTECTION AND RETENTION

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Quick Facts
Patent No.
US None
App. No.
13/886,788
Abstract

The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.

Claims (14)

1 . An ophthalmic composition comprising 0.1 to 0.2 w/v % galactomannan, 0.05 to 0.5 w/v % hyaluronic acid, and 1.0 to 2.0 w/v % cis-diol.

2 . A composition according to claim 1 comprising 0.17 to 0.18 w/v % guar, 0.13 to 0.17 w/v % sodium hyaluronate, and 1.4 w/v % sorbitol.

3 . A composition according to claim 1 wherein said galactomannan is selected from the group consisting of:

guar, hydroxylpropyl guar, and combinations thereof.

4 . A composition according to claim 1 wherein said cis-diol is selected from the group consisting of sorbitol, mannitol, polyethylene glycols, polypropylene glycols, polyethyleneoxide-polybutyleneoxide block copolymers, and combinations thereof.

5 . A composition according to claim 1 wherein said cis-diol is sorbitol or mannitol.

6 . A composition according to claim 5 wherein said cis-diol is present at a concentration of about 1.4 w/v %.

7 . A composition according to claim 1 wherein said borate is boric acid.

8 . A composition according to claim 1 further comprising a demulcent selected from the group consisting of:

glycerin, polyvinyl pyrrolidone, polyethylene oxide, polyethylene glycol, propylene glycol, polyacrylic acid, and combinations thereof.

9 . A composition according to claim 8 wherein said demulcent is polypropylene glycol or polyethylene glycol.

10 . A composition according to claim 1 further comprising a pharmaceutically active compound.

11 . A method for treating ophthalmic disease which comprises administering to a subject in need of such treatment a composition according to claim 1 .

12 . A method according to claim 10 , wherein the ophthalmic disease is dry eye.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 3, 2013
From: DAVIS, JAMES W.; KETELSON, HOWARD ALLEN; CAMPBELL, ELAINE E.; MEADOWS, DAVID L.; RANGARAJAN, REKHA
To: ALCON RESEARCH, LTD.
Reel/Frame 030348/0012 →