Modified pectins, compositions and methods related thereto
View Patent ↗The present invention provides compositions of modified pectin and methods for preparing and using them.
1. A liquid composition comprising colloidal particles of a purified, deesterified, and partially depolymerized modified pectin, wherein the colloidal particles of the purified, deesterified, and partially depolymerized modified pectin consist essentially of colloidal particles less than 1 micron in diameter and the composition is substantially free of modified pectins having molecular weights below 25 kD.
2. The composition of claim 1 , wherein the deesterified and partially depolymerized modified-pectin has an average molecular weight from 50-200 kD.
3. The composition of claim 2 , wherein the deesterified and partially depolymerized modified pectin has an average molecular weight from 80-150 kD.
4. The method of claim 3 , wherein the deesterified and partially depolymerized modified pectin has an average molecular weight from 80-100 kD.
5. The composition of claim 1 , wherein the composition is an aqueous solution.
6. The composition of claim 5 , wherein the solution contains at least 0.5% by weight of the deesterified and partially depolymerized modified pectin.
7. The composition of claim 6 , wherein the solution contains at least 5% by weight of the deesterified and partially depolymerized modified pectin.
8. The composition of claim 1 , wherein the composition is a colloidal suspension.
9. The composition of claim 1 , wherein the colloidal particles are less than 0.20 μm in diameter.
10. The composition of claim 1 , wherein the deesterified and partially depolymerized modified pectin inhibits cancer proliferation with an IC 50 less than 200 μg/mL.
11. The composition of claim 10 , wherein the deesterified and partially depolymerized modified pectin inhibits cancer proliferation with an IC 50 in the range of 25-75 μg/mL.
12. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and the composition of claim 1 .
13. A dosage form comprising the composition of claim 1 , wherein the dosage form is selected from dosage forms suitable for oral dosage, topical application, and inhalation.
14. The dosage form of claim 13 , wherein the dosage form is suitable for oral dosage.
15. A dosage form comprising the composition of claim 1 , wherein the dosage form is suitable for parenteral administration.
16. The dosage form of claim 15 , wherein the parenteral administration is selected from injection or intravenous infusion.
17. A method comprising parenterally administering the composition of claim 1 to a patient in need thereof.
18. A method comprising orally administering the composition of claim 1 to a patient in need thereof.
19. The composition of claim 1 , wherein the composition is a colloidal solution.