Detecting infection in reduced pressure wound treatment
View Patent ↗Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.
1. A system for detecting an infection at a wound site, the system comprising:
a source of reduced pressure;
a porous pad adapted to deliver the reduced pressure to the wound site;
a drape adapted to provide a substantially airtight cover over the porous pad and the wound site;
a conduit fluidly connecting the porous pad to the source of reduced pressure, wherein the conduit is configured to withdraw fluid from the wound site in response to the reduced pressure; and
a sensor adapted to identify a product of the infection or a component of an infecting organism in fluid withdrawn from the wound site;
whereby the presence of the product or the component indicates the presence of an infection in the wound.
2. The system of claim 1 , wherein the sensor comprises a photodetector and the porous pad further comprises luciferase and luciferin.
3. The system of claim 2 , wherein the luciferase is covalently bound to the porous pad.
4. The system of claim 1 , wherein the sensor comprises a compartment for placing a substrate comprising bound antibodies, the compartment adapted to allow fluid to flow onto the antibodies as fluid is drawn from the wound.
5. The system of claim 1 , wherein the sensor comprises a limulus amebocyte lysate.
6. The system of claim 1 , wherein the sensor comprises a microarray.
7. The system of claim 6 , wherein the microarray is in the reduced pressure source.
8. The system of claim 1 , further comprising a computer capable of recording data from the sensor.
9. A porous pad adapted for distributing reduced pressure to a wound site, wherein the pad comprises luciferase.
10. The porous pad of claim 9 , wherein the luciferase is covalently bound to the pad.
11. The porous pad of claim 9 , further comprising luciferin.