Drug eluting medical implant
Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
1. A medical implant comprising:
a tubular structure comprising a first polymeric material;
a first conformal coating comprising poly (lactic acid-co-caprolactone), said first conformal coating at least partially coating said tubular structure and increasing the mass of said tubular structure by at least about 20 percent;
a second conformal coating at least partially coating said first conformal coating and comprising a second polymeric material and paclitaxel, said second conformal coating comprising between 0.3 weight percent and 5 weight percent of paclitaxel; and
a third conformal coating at least partially coating said second conformal coating and comprising a third polymeric material.
2. The medical implant of claim 1 , wherein said poly (lactic acid-co-caprolactone) comprises about 50 weight percent of lactic acid and about 50 weight percent of caprolactone.
3. The medical implant of claim 1 , wherein said poly (lactic acid-co-caprolactone) is prepared by a process that comprises the step of crosslinking said poly (lactic acid-co-caprolactone) with diisocyanate.
4. The medical implant of claim 3 , wherein said diisocyanate is hexamethylene diisocyanate.
5. The medical implant of claim 1 , wherein said first polymeric material comprises poly(lactic acid co-glycolic acid).
6. The medical implant of claim 1 , wherein said second conformal coating has a thickness up to 8 microns.
7. The medical implant of claim 1 , wherein the medical implant comprises between 2.5 micrograms and 20 micrograms of paclitaxel per 10 millimeters of length of the tubular structure.
8. The medical implant of claim 7 , wherein the medical implant comprises between 5 micrograms and 13 micrograms of paclitaxel per 10 millimeters of length of the tubular structure.
9. The medical implant of claim 1 , wherein the third conformal coating is biodegradable.
10. The medical implant of claim 1 , wherein at least a portion of said third conformal coating does not include paclitaxel.
11. The medical implant of claim 1 , wherein said second and third polymeric materials are the same.
12. The medical implant of claim 1 , wherein said second and third polymeric materials are different.
13. A medical implant comprising:
a tubular structure comprising a first polymeric material;
a first conformal coating comprising poly (lactic acid-co-caprolactone), said first conformal coating at least partially coating said tubular structure and increasing the mass of said tubular structure by at least about 20 percent;
a second conformal coating at least partially coating said first conformal coating and comprising a second polymeric material and paclitaxel, said second conformal coating comprising between 2.5 micrograms and 20 micrograms of paclitaxel per 10 millimeters of length of the tubular structure; and
a third conformal coating at least partially coating said second conformal coating and comprising a third polymeric material.
14. The medical implant of claim 13 , wherein said second conformal coating comprises between 5 micrograms and 13 micrograms of paclitaxel per 10 millimeters of length of the tubular structure.
15. The medical implant of claim 13 , wherein said poly (lactic acid-co-caprolactone) comprises about 50 weight percent of lactic acid and about 50 weight percent of caprolactone.
16. The medical implant of claim 13 , wherein said poly (lactic acid-co-caprolactone) is prepared by a process that comprises the step of crosslinking said poly (lactic acid-co-caprolactone) with diisocyanate.
17. The medical implant of claim 16 , wherein said diisocyanate is hexamethylene diisocyanate.
18. The medical implant of claim 13 , wherein said first polymeric material comprises poly(lactic acid co-glycolic acid).
19. The medical implant of claim 13 , wherein said second conformal coating has a thickness up to 8 microns.
20. The medical implant of claim 13 , wherein the second conformal coating comprises between 0.3 weight percent and 5 weight percent of paclitaxel.
21. The medical implant of claim 13 , wherein the third conformal coating is biodegradable.
22. The medical implant of claim 13 , wherein at least a portion of said third conformal coating does not include paclitaxel.
23. The medical implant of claim 13 , wherein said second and third polymeric materials are the same.
24. The medical implant of claim 13 , wherein said second and third polymeric materials are different.