IP Library Granted Patent US 9,216,290
Granted Patent B2
US 9,216,290 · App. 13/893,292 · Granted Dec 22, 2015

Cranial nerve stimulation for treatment of substance addiction

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Quick Facts
Patent No.
US 9,216,290
App. No.
13/893,292
Granted
Dec 22, 2015
Kind
B2
Abstract

A method of treating a patient with at least one substance addiction, which comprises directly stimulating a cranial nerve, such as the vagus nerve, of a patient with an electrical pulse signal defined by a plurality of parameters to provide a therapy regimen for alleviating a symptom associated with the substance addiction.

Claims (17)

1. A method of treating a patient having a substance addiction, comprising: operatively coupling a first electrode to a first cranial nerve of the patient; applying a first electrical signal to the first cranial nerve of the patient in a first treatment period to alleviate an acute symptom of the substance addiction; directly coupling a second electrode to a second cranial nerve of the patient; applying a second electrical signal to the second cranial nerve of the patient in a second treatment period to treat a chronic symptom of the substance addiction, wherein the first electrical signal is different than the second electrical signal.

2. The method of claim 1 wherein the first cranial nerve of the patient is a trigeminal nerve.

3. The method of claim 1 wherein the first cranial nerve of the patient is a glossopharyngeal nerve.

4. The method of claim 1 wherein the acute symptom is selected from the group comprising: nausea; vomiting; fever; dizziness; and profuse sweating.

5. The method of claim 1 wherein the chronic symptom comprises compulsive substance craving.

6. The method of claim 1 wherein the substance is selected from the group comprising: cocaine; alcohol; opioids; barbiturates; benzodiazepines; cannabis; amphetamines; nicotine; and phencyclidine.

7. The method of claim 1 wherein the first electrode comprises an external electrode coupled to skin of the patient.

8. The method of claim 1 wherein the second cranial nerve of the patient is a vagus nerve.

9. A method of treating a patient having a substance addiction, comprising: operatively coupling a first electrode to a first portion of a cranial nerve of the patient; applying a first electrical signal to the first portion of the cranial nerve of the patient in a first treatment period to alleviate an acute symptom of the substance addiction; directly coupling a second electrode to a second portion of the cranial nerve of the patient; applying a second electrical signal to the second portion of the cranial nerve of the patient in a second treatment period to treat a chronic symptom of the substance addiction, wherein the first electrical signal is different than the second electrical signal.

10. The method of claim 9 wherein the cranial nerve of the patient is a vagus nerve.

11. The method of claim 9 wherein the acute symptom is selected from the group comprising: nausea; vomiting; fever; dizziness; and profuse sweating.

12. The method of claim 9 wherein the chronic symptom comprises compulsive substance craving.

13. The method of claim 9 wherein the substance is selected from the group comprising: cocaine; alcohol; opioids; barbiturates; benzodiazepines; cannabis; amphetamines; nicotine; and phencyclidine.

14. The method of claim 9 wherein the first electrode comprises an external electrode coupled to skin of the patient.

15. A system for treating a patient having a substance addiction, comprising: a first electrode operatively coupled to a first cranial nerve of the patient, wherein a first electrical signal is applied to the first cranial nerve of the patient in a first treatment period to alleviate an acute symptom of the substance addiction; a second electrode directly coupled to a second cranial nerve of the patient, wherein a second electrical signal is applied to the second cranial nerve of the patient in a second treatment period to treat a chronic symptom of the substance addiction, wherein the first electrical signal is different than the second electrical signal.

16. The method of claim 15 wherein the acute symptom is selected from the group comprising: nausea; vomiting; fever; dizziness; and profuse sweating.

17. The method of claim 15 wherein the chronic symptom comprises compulsive substance craving.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: LIVANOVA USA, INC.
Reel/Frame 057552/0378 →
SECURITY INTEREST Recorded Aug 16, 2021
From: LIVANOVA USA, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0001 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: LIVANOVA USA, INC.
Reel/Frame 057189/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: LIVANOVA USA, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0784 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: LIVANOVA USA, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 053673/0675 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED AT REEL: 037961 FRAME: 0417. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Mar 22, 2016
From: CYBERONICS, INC.
To: ZABARA, JACOB
Reel/Frame 038213/0207 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 1, 2016
From: CYBERONICS, INC.
To: ZABARA, JACOB
Reel/Frame 037961/0417 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 10, 2015
From: TERRY, REESE S.
To: CYBERONICS, INC.
Reel/Frame 034926/0238 →