Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
A plurality of artificial red blood cell particles includes each particle of the plurality being substantially monodisperse and each particle having a largest common linear dimension of about 5 μm to about 10 μm. The particles can also have a modulus configured such that a particle of the plurality of particles can pass through a tube having an inner diameter of less than about 3 μm.
1. A synthetic particle, comprising:
a substantially disc shaped, molded synthetic polymer particle having largest linear dimension of between about 5 μm to about 10 μm and a modulus of less than about 1 MPa, wherein the particle can pass through an opening of less than about 3 μm.
2. The synthetic particle of claim 1 , wherein the synthetic polymer comprises a biocompatible polymer.
3. The synthetic particle of claim 1 , wherein the synthetic polymer comprises poly(ethylene glycol), poly(lactic acid), poly(lactide-co-glycolide), poly(ethylene glycol) diacrylate, or trimethylolpropane triacrylate.
4. The synthetic particle of claim 1 , wherein the particle further comprises a cargo selected from the group consisting of a therapeutic agent, a biologic, a diagnostic agent, hemoglobin, and an imaging agent.
5. The synthetic particle of claim 4 , wherein the cargo is capable of binding and releasing oxygen.
6. The synthetic particle of claim 1 , wherein the opening is an orifice, an opening of a tube or a lumen.
7. A drug delivery particle, comprising:
a substantially disc shaped, molded synthetic polymer particle having a largest linear dimension less than about 10 μm and a modulus of less than about 1 MPa, wherein the particle can pass through an opening less than about 60% the largest linear dimension of the particle.
8. The drug delivery particle of claim 7 , wherein the particle can pass through an opening of less than about 37.5% the largest linear dimension of the particle.
9. The drug delivery particle of claim 7 , wherein the particle can pass through an opening of less than about 30% the largest linear dimension of the particle.
10. The drug delivery particle of claim 7 , wherein the synthetic polymer comprises a biocompatible polymer.
11. The drug delivery particle of claim 7 , wherein the synthetic polymer comprises poly(ethylene glycol), poly(lactic acid), poly(lactide-co-glycolide), poly(ethylene glycol) diacrylate, or trimethylolpropane triacrylate.
12. The drug delivery particle of claim 7 , wherein the particle further comprises a cargo selected from the group consisting of a therapeutic agent, a biologic, a diagnostic agent, hemoglobin, and an imaging agent.
13. The drug delivery particle of claim 7 , wherein the opening is an orifice, an opening of a tube or a lumen.