IP Library › Granted Patent US 9,198,951
Granted Patent B2
US 9,198,951 · App. 13/904,654 · Granted Dec 1, 2015

Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure

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Quick Facts
Patent No.
US 9,198,951
App. No.
13/904,654
Granted
Dec 1, 2015
Kind
B2
Abstract

The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.

Claims (8)

1. A method for treating heart failure in a human, said method comprising:

administering a therapeutically effective amount of a peptide comprising an epidermal growth factor-like (EGF-like) domain of GGF2 to the human at an interval of at least 96 hours, wherein said therapeutically effective amount is effective to treat heart failure in said human.

2. The method of claim 1 , wherein said administering is performed every 96 hours.

3. The method of claim 1 , wherein said administration is performed on a regimen selected from the group consisting of every: four days, one week, 10 days, 14 days, one month, two months, three months or four months.

4. The method of claim 1 , wherein said peptide is recombinant human GGF2.

5. The method of claim 1 , wherein the peptide is:

SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV

MASFYSTSTPFLSLPE. (SEQ ID NO: 4)

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 31, 2017
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: NEURONEX, INC.; CIVITAS THERAPEUTICS, INC.; ACORDA THERAPEUTICS, INC.
Reel/Frame 042643/0878 →
SECURITY INTEREST Recorded Jun 10, 2016
From: ACORDA THERAPEUTICS, INC.; CIVITAS THERAPEUTICS, INC.; NEURONEX, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 038950/0436 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2013
From: CAGGIANO, ANTHONY O.; GANGULY, ANINDITA; IACI, JENNIFER; PARRY, TOM
To: ACORDA THERAPEUTICS, INC.
Reel/Frame 031182/0556 →