Method for enhancing the bioavalability of ospemifene
View Patent ↗This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
1. A method of treating sexual dysfunction comprising orally administering a therapeutically effective amount of ospemifene or a pharmaceutically acceptable salt thereof to a patient in need thereof in connection with the intake of a foodstuff having nutritional value and causing secretion of bile acids to enhance bioavailability of the ospemifene or pharmaceutically acceptable salt thereof.
2. The method according to claim 1 wherein the ospemifene or pharmaceutically acceptable salt thereof is administered at a time point which is in the range defined by 1 hour before starting the food intake and 2 hours after starting the food intake.
3. The method according to claim 2 wherein the ospemifene or pharmaceutically acceptable salt thereof is administered at a time point which is in the range defined to begin at a time point during the food intake and to end 1 hour after the food intake was started.
4. The method according to claim 3 wherein the ospemifene or pharmaceutically acceptable salt thereof is administered at a time point which is no later than 0.5 hours after starting the food intake.
5. The method according to claim 2 wherein the ospemifene or pharmaceutically acceptable salt thereof is administered in oral dosage form and wherein the dosage amount is from 30 to 90 mg/day.
6. The method according to claim 5 wherein the dosage amount is 60 mg.
7. The method of claim 2 wherein said patient is a perimenopausal or postmenopausal woman.
8. The method according to claim 1 wherein said sexual dysfunction is dyspareunia.
9. The method according to claim 8 wherein the ospemifene or pharmaceutically acceptable salt thereof is administered in oral dosage form and wherein the dosage amount is from 30 to 90 mg/day.
10. The method according to claim 9 wherein the dosage amount is 60 mg.
11. The method of claim 10 where said patient is a perimenopausal or postmenopausal woman.
12. The method according to claim 1 wherein the ospemifene or pharmaceutically acceptable salt thereof is administered in oral dosage form and wherein the dosage amount is from 30 to 90 mg/day.
13. The method according to claim 12 wherein the dosage amount is 60 mg.
14. The method of claim 1 wherein said patient is a perimenopausal or a postmenopausal woman.
15. A method of treating sexual dysfunction comprising orally administering a therapeutically effective amount of ospemifene to a patient in need thereof in connection with the intake of a foodstuff having nutritional value and causing secretion of bile acids to enhance bioavailability of the ospemifene or pharmaceutically acceptable salt thereof.
16. The method according to claim 15 , wherein the ospemifene is administered at a time point which is in the range defined by 1 hour before starting the food intake and 2 hours after starting the food intake.
17. The method according to claim 15 , wherein said sexual dysfunction is dyspareunia.
18. The method according to claim 17 , wherein the dosage amount is 60 mg.
19. The method of claim 17 , wherein said patient is a perimenopausal or a postmenopausal woman.