Method of applying an injectable filler

1. A method for providing a target area of a subject with a continuing increase in firmness, volume, or firmness and volume following a re-treatment session of an injectable filler composition, said method comprising:

performing an initial treatment session on the subject, said initial treatment session comprising a first injection of a hyaluronic acid, thereby providing an increase in volume, firmness, or volume and firmness to the target area; and

performing the re-treatment session on the subject, said re-treatment session comprising a second injection of the hyaluronic acid into the target area at a time subsequent to the initial treatment session but at a time before the subject displays an apparent need for application of an injectable filler, wherein the initial treatment and the re-treatment session are spaced apart in time to result in the subject maintaining at least a 1 point improvement in a global aesthetic improvement scale score for 18 months after the initial treatment session.

2. The method of claim 1 , wherein the subject receives no additional injections of said hyaluronic acid to the target area for 18 months after the initial treatment session, except for the re-treatment session.

3. The method of claim 1 , wherein the subject's global aesthetic improvement scale continues to improve for at least 9 months following the re-treatment session.

4. The method of claim 1 , wherein the subject's global aesthetic improvement scale continues to improve for at least 13 months following the re-treatment session.

5. The method of claim 1 , wherein the subject maintains at least a 3 point improvement in the global aesthetic improvement scale score for 18 months after the initial treatment session.

6. The method of claim 1 , wherein the re-treatment session is performed 1-9 months after the initial treatment session.

7. The method of claim 1 , wherein the hyaluronic acid comprises cross-linked hyaluronic acid.

8. The method of claim 1 , wherein the hyaluronic acid comprises a non-animal-stabilized hyaluronic acid.

9. The method of claim 1 , wherein the initial treatment session results in a full correction of the target area.

10. The method of claim 1 , wherein the initial treatment session comprises the first injection and a touch-up application within less than 1 month of the first injection.

11. The method of claim 1 , wherein a rate of absorption of the second injection of the hyaluronic acid is slowed due to the initial treatment session.

12. A method for providing a target area of a subject with a continuing increase in firmness, volume, or firmness and volume following a re-treatment session of an injectable filler composition, said method comprising:

identifying a subject that will benefit from a continuing increase in a volume, firmness, or firmness and volume of a target area during a period following a re-treatment session, wherein the volume, firmness, or firmness and volume increases throughout the period;

performing an initial treatment session on the subject, said initial treatment session comprising a first injection of a hyaluronic acid, thereby providing an increase in volume, firmness, or firmness and volume to the target area; and

performing the re-treatment session on the subject, said re-treatment session comprising a second injection of the hyaluronic acid into the target area at a time subsequent to the initial treatment session but at a time before the subject displays an apparent need for application of an injectable filler, wherein the initial treatment and the re-treatment session are spaced to result in the subject maintaining at least a one point improvement in a wrinkle severity rating score for 18 months after the initial treatment session.

13. The method of claim 12 , wherein the subject receives no additional injections of said hyaluronic acid to the target area, except for the initial treatment session and the re-treatment session.

14. The method of claim 13 , wherein the at least one point improvement in the wrinkle severity rating score is maintained for at least 12 months after the re-treatment session.

15. The method of claim 13 , wherein the at least one point improvement in the wrinkle severity rating score is maintained for at least 13.5 months after the re-treatment session.

16. The method of claim 12 , wherein the re-treatment session occurs no earlier than 3 months after the initial treatment session.

17. The method of claim 12 , wherein the hyaluronic acid comprises cross-linked hyaluronic acid.

18. The method of claim 12 , wherein the re-treatment session comprises administering no more than 60 percent of an amount of the first injection of the hyaluronic acid used in the initial treatment session.

19. A method for providing a target area of a subject with a continuing increase in firmness and/or volume following a re-treatment session of an injectable filler composition, said method comprising:

performing an initial treatment session on the subject, said initial treatment session comprising a first injection of a hyaluronic acid, thereby providing an increase in volume and/or firmness to the target area; and

performing the re-treatment session on the subject, said re-treatment session comprising a second injection of a hyaluronic acid into the target area at a time subsequent to the initial treatment session but at a time before the subject displays an apparent need for application of an injectable filler, wherein the initial treatment and the re-treatment session are timed such that an improvement score for the target area continues to improve for at least 10.5 months following the re-treatment.

20. The method of claim 19 , wherein the first injection of the hyaluronic acid comprises non-animal-stabilized hyaluronic acid, and wherein and the second injection of the hyaluronic acid comprises non-animal-stabilized hyaluronic acid.