IP Library › Granted Patent US 8,765,957
Granted Patent B2
US 8,765,957 · App. 13/908,349 · Granted Jul 1, 2014

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Inventors: John DeMattei (Berthoud, CO); Adam R. Looker (Winchester, MA); Bobbianna Neubert-Langille (Sudbury, MA); Martin Trudeau (Shannon, CA); Stefanie Roeper (Medford, MA); Michael P. Ryan (Roxbury, MA); Dahrika Milfred Yap Guerette (Cambridge, MA); Brian R. Krueger (Cambridge, MA); Peter D. J. Grootenhuis (San Diego, CA); Fredrick F. Van Goor (San Diego, CA); Martyn C. Botfield (Concord, MA); Gregor Zlokarnik (La Jolla, CA)
Assignee: Vertex Pharmaceuticals Incorporated
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Quick Facts
Patent No.
US 8,765,957
App. No.
13/908,349
Granted
Jul 1, 2014
Kind
B2
Abstract

The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

Claims (4)

1. A compound selected from Compound 32 and Compound 33:

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 , wherein the compound is Compound 32.

3. The compound according to claim 1 , wherein the compound is Compound 33.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
ASSIGNEE CHANGE OF ADDRESS Recorded Feb 12, 2016
From: VERTEX PHARMACEUTICALS INCORPORATED
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 037812/0341 →
SECURITY INTEREST Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2013
From: DEMATTEI, JOHN; LOOKER, ADAM R.; ROEPER, STEFANIE; RYAN, MICHAEL P.; YAP, DAHRIKA MILFRED LAO; KRUEGER, BRIAN R.; BOTFIELD, MARTYN C.; NEUBERT-LANGILLE, BOBBIANNA; TRUDEAU, MARTIN; GROOTENHUIS, PETER D.J.; VAN GOOR, FREDRICK F.; ZLOKARNIK, GREGOR
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 031165/0734 →
Continuity (5)
Continuation 12728173 · Mar 19, 2010
Provisional Application 61162148 · Mar 20, 2009
Provisional Application 61246303 · Sep 28, 2009
Provisional Application 61248565 · Oct 5, 2009
Related Publication 20140012003A1 · Jan 9, 2014