IP Library › Granted Patent US 9,442,120
Granted Patent B2
US 9,442,120 · App. 13/912,531 · Granted Sep 13, 2016

Biomarkers associated with nephropathy

Inventors: Tzu-Ling Tseng (Xinzhuang, TW); Ching-Fang Lu (Zhubei, TW); Wei-Ya Lin (Dali, TW); Tsai-Wei Hsu (Miaoli County, TW); Mary Ya-Ping Yeh (Taipei, TW); Yi-Ting Chen (Taoyuan County, TW); Chwei-Shiun Yang (Taipei, TW)
Assignee: Industrial Technology Research Institute
G01N33/6893C07K14/70503C07K16/2803G01N2333/4728G01N2333/70503G01N2800/347G01N2800/52G01N2800/56
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Quick Facts
Patent No.
US 9,442,120
App. No.
13/912,531
Granted
Sep 13, 2016
Kind
B2
Abstract

Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.

Claims (4)

1. A method of detecting, in a urine sample, the level of a fragment of leukocyte-associated Ig-like receptor-2 consisting of the sequence of SEQ ID NO:1, wherein the detecting step is performed with an immune assay.

2. The method of claim 1 , wherein the immune assay is Western blot, ELISA, radioimmunoassay (RIA), fluorescent immunoassay (FIA), or luminescence immunoassay (LIA).

3. The method of claim 1 , wherein the urine sample is obtained from a human subject.

4. The method of claim 1 , wherein the urine sample is obtained from a laboratory animal.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2018
From: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
To: BIO PREVENTIVE MEDICINE CORP.
Reel/Frame 046367/0018 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 1, 2013
From: TSENG, TZU-LING; LU, CHING-FANG; LIN, WEI-YA; HSU, TSAI-WEI; YEH, MARY YA-PING; CHEN, YI-TING; YANG, CHWEI-SHIUN
To: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Reel/Frame 030721/0894 →
Continuity (4)
Continuation 12969731 · Dec 16, 2010
Continuation 12694639 · Jan 27, 2010
Provisional Application 61147785 · Jan 28, 2009
Related Publication 20130266976A1 · Oct 10, 2013