BIOLOGIC BONDING AGENT
A sterile biofilm could be engineered to isolate the glue-like substance while eliminating the adverse properties of the bacteria. The resulting sterile glue-like substance would be used to help the cells stick to the support structure. The engineered biofilm could be added to the support structure in the laboratory that produces the support structure or just prior to the addition of the cells by the user. Alternatively, the biofilm and support structure could be combined intra-corporally. This biofilm also could be used as an independent polysaccharide based adhesive with mild to moderate adhesion forces. The biofilm could serve as a surgical adhesion or grouting for cells, for tissue fixation (soft tissue to soft tissue, soft tissue to bone, etc.) and as a sealant. The biofilm could be used in conjunction with other implants and devices. The biofilm could be used to coat a stent.
1 . A biologic bonding agent comprising:
an engineered adhesive derived at least in part from a bacterial source; and
the adhesive being configured to be collected, processed to be substantially free of viable bacteria, and placed in a container,
wherein adhesive properties of the bacterial source are substantially maintained.
2 . The bonding agent of claim 1 , wherein the bacterial source includes biofilm.
3 . The bonding agent of claim 1 , wherein at least a portion of the adhesive is polysaccharide based.
4 . The bonding agent of claim 1 , wherein the adhesive is configured to be coated on or impregnated in at least a portion of an implant.
5 . The bonding agent of claim 1 , wherein at least a portion of the adhesive is biodegradable.
6 . The bonding agent of claim 1 , wherein the adhesive is configured to be coated on or impregnated in at least a portion of a stent.
7 . The bonding agent of claim 1 , wherein the adhesive is configured to be applied to at least a portion of a collagen material.
8 . The bonding agent of claim 1 , wherein the adhesive is configured to promote attachment of cells to a scaffold.
9 . The bonding agent of claim 1 , wherein the adhesive is configured to be applied to at least a portion of a body tissue.
10 . The bonding agent of claim 1 , wherein the adhesive is a surgical adhesive.
11 . The bonding agent of claim 1 , wherein the adhesive is a grouting agent.
12 . The bonding agent of claim 1 , wherein the adhesive is configured to adhere soft tissue to soft tissue.
13 . The bonding agent of claim 1 , wherein the adhesive is configured to adhere soft tissue to bone.
14 . The bonding agent of claim 1 , wherein the adhesive is a sealant.
15 . The bonding agent of claim 1 , wherein the adhesive is configured to repair a body portion.
16 . The bonding agent of claim 1 , wherein the adhesive is configured to repair a portion of a blood vessel.
17 . The bonding agent of claim 1 , wherein the adhesive is configured to be positioned in a body with a cannula.
18 . The bonding agent of claim 1 , wherein the adhesive includes a plasticizer.
19 . The bonding agent of claim 1 , wherein the adhesive includes an antibiotic.
20 . The bonding agent of claim 1 , wherein the adhesive includes a therapeutic substance.
21 . A biologic bonding agent comprising:
a polysaccharide based adhesive derived at least in part from a bacterial source; and
the adhesive being configured to be processed to be substantially free of viable bacteria,
wherein the adhesive configured to adhere to a portion of a body.
22 . The bonding agent of claim 21 , wherein the bacterial source includes biofilm.
23 . The bonding agent of claim 21 , wherein the adhesive is configured to be coated on or impregnated in at least a portion of an implant.
24 . The bonding agent of claim 21 , wherein at least a portion of the adhesive is biodegradable.
25 . The bonding agent of claim 21 , wherein the grouting agent is configured to be applied to at least a portion of a collagen material.
26 . The bonding agent of claim 21 , wherein the adhesive is configured to promote attachment of cells to a scaffold.
27 . The bonding agent of claim 21 , wherein the adhesive is a surgical adhesive.
28 . The bonding agent of claim 21 , wherein the adhesive is a grouting agent.
29 . The bonding agent of claim 21 , wherein the adhesive is configured for tissue fixation.
30 . The bonding agent of claim 21 , wherein the adhesive includes a sealant.
31 . The bonding agent of claim 21 , wherein the adhesive includes a plasticizer.
32 . The bonding agent of claim 21 , wherein the adhesive includes an antibiotic.
33 . The bonding agent of claim 21 , wherein the adhesive includes a therapeutic substance.
34 . A biologic bonding agent comprising:
a grouting agent derived at least in part from biofilm; and
the grouting agent configured to be processed to substantially reduce viable bacteria,
wherein the grouting agent is configured to grout a portion of an object.
35 . The bonding agent of claim 34 , wherein at least a portion of the grouting agent is polysaccharide based.
36 . The bonding agent of claim 34 , wherein the adhesive is configured to be applied to at least a portion of a scaffold.
37 . The bonding agent of claim 34 , wherein the grouting agent is a sealant.
38 . The bonding agent of claim 34 , wherein the grouting agent includes a plasticizer.