LOCAL TOPICAL ADMINISTRATION FORMULATIONS CONTAINING INDOXACARB
The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.
1 . A local, topical, spot-on formulation for control of ectoparasites on a domestic animal comprising an ectoparasitically effective amount of Indoxacarb, a veterinarily acceptable carrier, and a pyrethroid pesticide.
2 . The formulation of claim 1 , wherein said ectoparasite is an Arthropod.
3 . The formulation of claim 2 , wherein said Arthropod is an Insecta.
4 . The formulation of claim 3 , wherein said Insecta is a flea, fly, or louse.
5 . The formulation of claim 2 , wherein said Arthropod is an Arachnida.
6 . The formulation of claim 1 , wherein the concentration of Indoxacarb in said formulation is at least 200 g/L.
7 . The formulation of claim 1 , wherein the concentration of Indoxacarb in said formulation is at least 150 g/L.
8 . The formulation of claim 1 , wherein the concentration of Indoxacarb is at least 100 g/L.
9 . The formulation of claim 1 , wherein said veterinarily acceptable carrier comprises one or more of a solvent, crystallization inhibitor, adjuvant, co-solvent, colorant, surfactant, spreading oil, antioxidant, light stabilizer or tackifier.
10 . The formulation of claim 9 , wherein said solvent comprises a glycol ether.
11 . The formulation of claim 10 , wherein said glycol ether comprises dipropylene glycol monomethyl ether.
12 . The formulation of claim 9 , wherein said solvent comprises an alkyl acetate.
13 . The formulation of claim 12 , wherein said alkyl acetate is ethyl acetoacetate.
14 . The formulation of claim 9 , wherein said crystallization inhibitor is triacetin.
15 . The formulation of claim 1 , wherein said domestic animal is a mammal.
16 . The formulation of claim 15 , wherein said mammal is a canine or feline.
17 - 24 . (canceled)
25 . A method for the control of ectoparasites on a domestic animal comprising topically applying to a localized region having a surface area of less than or equal to 10% of the total surface area of said domestic animal the formulation of claim 1 .
26 . The method of claim 25 , wherein said localized region has a surface area less than or equal to 5% of the total surface area of said domestic animal.
27 . The method of claim 25 , wherein said domestic animal is a canine or a feline and said localized region of said canine or feline is less than 10 cm 2 .
28 . The method of claim 25 , wherein said formulation maintains persistent efficacy on said domestic animal to the extent that no less than 5% decrease in efficacy occurs within 1 month after application of said formulation.
29 . The method of claim 25 , wherein said formulation maintains persistent efficacy on said domestic animal to the extent that no less than 5% decrease in efficacy occurs after 1 aqueous solution washing of said domestic animal.
30 - 39 . (canceled)
40 . The formulation of claim 1 , wherein said pyrethroid pesticide is permethrin.
41 . The formulation of claim 40 , said formulation comprising, by weight
1-50% Indoxacarb;
0.05-80% permethrin; and
ethyl acetoacetate.
42 . The formulation of claim 40 , said formulation comprising, by weight
1-50% Indoxacarb;
0.05-80% permethrin; and
dipropylene glycol monomethyl ether.
43 . The formulation of claim 40 , said formulation comprising, by weight
5-25% Indoxacarb;
30-75% permethrin; and
ethyl acetoacetate.
44 . The formulation of claim 40 , said formulation comprising, by weight
5-25% Indoxacarb;
30-75% permethrin; and
dipropylene glycol monomethyl ether.