Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
1. A method of inhibiting activity of c-Met kinase comprising contacting said kinase with a compound which is:
2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide;
or
2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo [1,2-b][1,2,4]triazin-2-yl]benzamide;
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein said compound is 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide.
3. The method of claim 1 , wherein said compound is 2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide.
4. The method of claim 1 , which is carried out in a cell.
5. The method of claim 4 , which is carried out in vitro.